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De Luca, V. et al.

De Luca, Zai, Tharmalingam, de Bartolomeis, Wong, Kennedy,

Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia.

A serotonin transporter gene linked polymorphic region (5-HTTLPR) has been investigated in several genetic association studies, including studies of schizophrenia and suicidality. The current study was designed to examine whether the new long (A/G) variant polymorphism of the 5-HTT gene may be associated with suicide attempts of 290 Caucasian schizophrenic patients. Among these patients, 92 had a history of suicide attempt. No association with history of suicide attempt was found in the multiallelic 5-HTTLPR (p = 0.305), however we found significant association with the intron 2 VNTR polymorphism (p = 0.018). When we performed a haplotype analysis, we found association between suicide attempt and haplotype distribution (p = 0.031). These findings suggest that the intron 2 VNTR polymorphism in serotonin transporter gene may influence suicidal behaviour in schizophrenia.[1]

References

Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia. De Luca, V., Zai, G., Tharmalingam, S., de Bartolomeis, A., Wong, G., Kennedy, J.L. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2006) [Pubmed]

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