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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Total synthesis of anthocyanidins via Heck reaction.

Anthocyanidin moiety was obtained by cyclization of a 2-hydroxychalcone prepared by the Heck approach to the synthesis of flavonoids. 1-(3,4-dimethoxyphenyl)-prop-2-en-1-one has been used as a coupling partner along with o-acetoxyiodobenzene in the Heck reaction.[1]


  1. Total synthesis of anthocyanidins via Heck reaction. Bianco, A., Cavarischia, C., Guiso, M. Nat. Prod. Res. (2006) [Pubmed]
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