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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

RFX-1, a putative alpha Adducin interacting protein in a human kidney library.

Adducin regulates tubular absorption of sodium by modulating the expression levels of the sodium-potassium-ATPase in renal tubular cells. Adducin is a candidate gene in the pathogenesis of hypertension. Yeast two hybrid screen showed a specific interaction between human alpha Adducin and the regulatory factor for X box (RFX-1), a nuclear protein that down regulates the expression of several proteins in non neuronal cells. The interaction was confirmed in cells through co-immunoprecipitation and colocalization experiments. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I.[1]


  1. RFX-1, a putative alpha Adducin interacting protein in a human kidney library. Boito, R., Menniti, M., Amato, R., Palmieri, C., Marinaro, C., Iuliano, R., Tripodi, G., Cusi, D., Fuiano, G., Perrotti, N. FEBS Lett. (2005) [Pubmed]
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