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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A role for LEDGF/ p75 in targeting HIV DNA integration.

HIV DNA integration is favored in active genes, but the underlying mechanism is unclear. Cellular lens epithelium-derived growth factor (LEDGF/ p75) binds both chromosomal DNA and HIV integrase, and might therefore direct integration by a tethering interaction. We analyzed HIV integration in cells depleted for LEDGF/ p75, and found that integration was (i) less frequent in transcription units, (ii) less frequent in genes regulated by LEDGF/ p75 and (iii) more frequent in GC-rich DNA. LEDGF is thus the first example of a cellular protein controlling the location of HIV integration in human cells.[1]


  1. A role for LEDGF/p75 in targeting HIV DNA integration. Ciuffi, A., Llano, M., Poeschla, E., Hoffmann, C., Leipzig, J., Shinn, P., Ecker, J.R., Bushman, F. Nat. Med. (2005) [Pubmed]
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