The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy.
The Ras-Raf-MAPK pathway has been implicated in lung carcinogenesis and, potentially, the maintenance of the malignant phenotype in these tumors. Mutations in ras and B-raf genes have been described in lung cancer, representing one of the few examples of tandem mutations in a signaling cascade. As a result, numerous approaches to inhibiting this pathway in lung cancer have been explored in the past decade. The most promising approach to date appears to be the inhibition of mitogen-activated ERK kinase or MEK. In this review, the potential utility of MEK inhibitors in the therapy of lung cancer is discussed.[1]References
- The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy. Adjei, A.A. Clinical lung cancer. (2005) [Pubmed]
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