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Rainero, I. et al.

Rainero, Fasano, Rubino, Rivoiro, Valfrè, Gallone, Savi, Gentile, Lo Giudice, De Martino, Dall'Omo, Pinessi,

Association between migraine and HLA-DRB1 gene polymorphisms.

We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.[1]

References

Association between migraine and HLA-DRB1 gene polymorphisms. Rainero, I., Fasano, E., Rubino, E., Rivoiro, C., Valfrè, W., Gallone, S., Savi, L., Gentile, S., Lo Giudice, R., De Martino, P., Dall'Omo, A.M., Pinessi, L. The journal of headache and pain : official journal of the Italian Society for the Study of Headaches. (2005) [Pubmed]

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