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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Transformation of revertant murine cells by 5-azacytidine results in rapid inhibition of lysyl oxidase expression.

Lysyl oxidase (LO) is synthesized intracellularly as a proenzyme that is secreted and then processed extracellularly to a mature form. LO is expressed in NIH3T3 cells, but only very low levels are observed after NIH 3T3 is transformed by c-H-ras or one of several other oncogenes. LO functions as a tumor suppressor. Treatment of ras-transformed cells with interferon-alpha with or without retinoic acid results in their persistent reversion to a non-transformed state that is dependent on the restoration of LO expression. When such revertant cells are treated with 5-azacytidine (5-azaC), they undergo rapid morphological retransformation. Within one passage after addition of 5-azaC, there was a down regulation of LO mRNA and proenzyme protein. These data suggest a direct relationship between the transformed state and LO expression.[1]

References

  1. Transformation of revertant murine cells by 5-azacytidine results in rapid inhibition of lysyl oxidase expression. Yeh, T.J., Contente, S., Friedman, R.M. Acta microbiologica et immunologica Hungarica. (2005) [Pubmed]
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