The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Narita, M. et al.

Narita, Kato, Kasukawa, Narita, Suzuki, Takeuchi, Suzuki,

Role of Src family kinase in the rewarding effect and hyperlocomotion induced by morphine.

The aim of the present study was to investigate the effect of a selective Src family kinase inhibitor, 4-amino-5-(4-chlorophenyl)-(t-butyl)pyrazolo[3,4-D]pyrimidine (PP2), on the rewarding effect and hyperlocomotion induced by morphine. An intracerebroventricular pretreatment with PP2 (0.1-10 nmol/mouse) significantly suppressed the morphine-induced rewarding effect and hyperlocomotion in a dose-dependent manner. We also investigated the changes in immunoreactivities to phosphorylated-Src family kinase in the nucleus accumbens of mice showing the morphine-induced rewarding effect. We found for the first time that Src family kinase is activated in the nucleus accumbens of mice showing the morphine-induced rewarding effect as compared with that found in saline-treated control mice. These findings suggest that Src family kinases in the nucleus accumbens are involved in the rewarding effect and hyperlocomotion induced by morphine.[1]

References

Role of Src family kinase in the rewarding effect and hyperlocomotion induced by morphine. Narita, M., Kato, H., Kasukawa, A., Narita, M., Suzuki, M., Takeuchi, T., Suzuki, T. Neuroreport (2006) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg