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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.

1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK(1) receptor antagonists. Substitution at the 6-exo-position led to high affinity NK(1) antagonists with a prolonged duration of action in vivo. Incorporation of an alpha-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.[1]


  1. 1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists. Huscroft, I.T., Carlson, E.J., Chicchi, G.G., Kurtz, M.M., London, C., Raubo, P., Wheeldon, A., Kulagowski, J.J. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
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