A greedy promoter controls malarial var-iations.
Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encode variant surface antigens. In a recent paper in Nature, demonstrate that a construct carrying a transcriptionally active var promoter is sufficient to promote allelic exclusion of the parasite's endogenous var gene.[1]References
- A greedy promoter controls malarial var-iations. Scherf, A. Cell (2006) [Pubmed]
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