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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.

The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi ribbon formation are known. Here, we demonstrate that ribbon formation is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65. Furthermore, these GM130 and GRASP65-dependent lateral cisternal-fusion reactions are necessary to achieve uniform distribution of enzymes in the Golgi ribbon. The membrane continuity created by ribbon formation facilitates optimal processing conditions in the biosynthetic pathway.[1]


  1. GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. Puthenveedu, M.A., Bachert, C., Puri, S., Lanni, F., Linstedt, A.D. Nat. Cell Biol. (2006) [Pubmed]
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