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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review

GLG1  -  golgi glycoprotein 1

Homo sapiens

Synonyms: CFR-1, CFR1, Cysteine-rich fibroblast growth factor receptor, E-selectin ligand 1, ESL-1, ...
 
 
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Disease relevance of GLG1

 

Psychiatry related information on GLG1

 

High impact information on GLG1

 

Chemical compound and disease context of GLG1

 

Biological context of GLG1

 

Anatomical context of GLG1

 

Associations of GLG1 with chemical compounds

 

Physical interactions of GLG1

 

Enzymatic interactions of GLG1

  • We previously reported that BACE1 also cleaved alpha2,6-sialyltransferase (ST6Gal I) in the Golgi apparatus and induced its secretion from the cell [31].
  • Changes in ER expression were studied in relation to early Alzheimer changes (i.e. hyperphosphorylated tau) and neuronal metabolism in AD as determined by the size of the Golgi apparatus (GA) or cell size [32].
 

Co-localisations of GLG1

 

Regulatory relationships of GLG1

 

Other interactions of GLG1

  • We used a monoclonal antibody (10A8), derived from mice immunized with fractions enriched in Golgi apparatus of rat brain neurons, to isolate an intrinsic membrane sialoglycoprotein of 160 KD from rat brain [3].
  • Phosphorylation of Nir2 by Cdk1 facilitates its dissociation from the Golgi apparatus, and phospho-Nir2(pS382) is localized in the cleavage furrow and midbody during cytokinesis [43].
  • The E-selectin ligand activity of CD44 is conferred by the elaboration of sialylated, fucosylated binding determinants on N-glycans [44].
  • ST6Gal I was colocalized with BACE1 in the Golgi apparatus by immunofluorescence microscopy, suggesting that BACE1 acts on ST6Gal I within the same intracellular compartment [45].
  • Overexpression of ARNO3 in mammalian cells results in (i) fragmentation of the Golgi apparatus, (ii) redistribution of Golgi resident proteins as well as the coat component beta-COP, and (iii) inhibition of SEAP transport (secreted form of alkaline phosphatase) [38].
 

Analytical, diagnostic and therapeutic context of GLG1

References

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  43. Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Litvak, V., Argov, R., Dahan, N., Ramachandran, S., Amarilio, R., Shainskaya, A., Lev, S. Mol. Cell (2004) [Pubmed]
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