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Gene Review

GLG1  -  golgi glycoprotein 1

Homo sapiens

Synonyms: CFR-1, CFR1, Cysteine-rich fibroblast growth factor receptor, E-selectin ligand 1, ESL-1, ...
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Disease relevance of GLG1


Psychiatry related information on GLG1


High impact information on GLG1


Chemical compound and disease context of GLG1


Biological context of GLG1


Anatomical context of GLG1


Associations of GLG1 with chemical compounds


Physical interactions of GLG1


Enzymatic interactions of GLG1

  • We previously reported that BACE1 also cleaved alpha2,6-sialyltransferase (ST6Gal I) in the Golgi apparatus and induced its secretion from the cell [31].
  • Changes in ER expression were studied in relation to early Alzheimer changes (i.e. hyperphosphorylated tau) and neuronal metabolism in AD as determined by the size of the Golgi apparatus (GA) or cell size [32].

Co-localisations of GLG1


Regulatory relationships of GLG1


Other interactions of GLG1

  • We used a monoclonal antibody (10A8), derived from mice immunized with fractions enriched in Golgi apparatus of rat brain neurons, to isolate an intrinsic membrane sialoglycoprotein of 160 KD from rat brain [3].
  • Phosphorylation of Nir2 by Cdk1 facilitates its dissociation from the Golgi apparatus, and phospho-Nir2(pS382) is localized in the cleavage furrow and midbody during cytokinesis [43].
  • The E-selectin ligand activity of CD44 is conferred by the elaboration of sialylated, fucosylated binding determinants on N-glycans [44].
  • ST6Gal I was colocalized with BACE1 in the Golgi apparatus by immunofluorescence microscopy, suggesting that BACE1 acts on ST6Gal I within the same intracellular compartment [45].
  • Overexpression of ARNO3 in mammalian cells results in (i) fragmentation of the Golgi apparatus, (ii) redistribution of Golgi resident proteins as well as the coat component beta-COP, and (iii) inhibition of SEAP transport (secreted form of alkaline phosphatase) [38].

Analytical, diagnostic and therapeutic context of GLG1


  1. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Crnogorac-Jurcevic, T., Efthimiou, E., Capelli, P., Blaveri, E., Baron, A., Terris, B., Jones, M., Tyson, K., Bassi, C., Scarpa, A., Lemoine, N.R. Oncogene (2001) [Pubmed]
  2. Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas. Yamaguchi, F., Morrison, R.S., Gonatas, N.K., Takahashi, H., Sugisaki, Y., Teramoto, A. Int. J. Oncol. (2003) [Pubmed]
  3. Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus. Croul, S., Mezitis, S.G., Stieber, A., Chen, Y.J., Gonatas, J.O., Goud, B., Gonatas, N.K. J. Histochem. Cytochem. (1990) [Pubmed]
  4. The Golgi apparatus at the cell centre. Rios, R.M., Bornens, M. Curr. Opin. Cell Biol. (2003) [Pubmed]
  5. Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Wang, H.Q., Nakaya, Y., Du, Z., Yamane, T., Shirane, M., Kudo, T., Takeda, M., Takebayashi, K., Noda, Y., Nakayama, K.I., Nishimura, M. Hum. Mol. Genet. (2005) [Pubmed]
  6. Effects of ethanol on lipid metabolism. Baraona, E., Lieber, C.S. J. Lipid Res. (1979) [Pubmed]
  7. Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. Sakurai, A., Okamoto, K., Fujita, Y., Nakazato, Y., Wakabayashi, K., Takahashi, H., Gonatas, N.K. Acta Neuropathol. (2000) [Pubmed]
  8. Fragmentation of the Golgi apparatus of Betz cells in patients with amyotrophic lateral sclerosis. Fujita, Y., Okamoto, K., Sakurai, A., Amari, M., Nakazato, Y., Gonatas, N.K. J. Neurol. Sci. (1999) [Pubmed]
  9. Compartmentalized ras/mapk signaling. Mor, A., Philips, M.R. Annu. Rev. Immunol. (2006) [Pubmed]
  10. A genetic approach to Mammalian glycan function. Lowe, J.B., Marth, J.D. Annu. Rev. Biochem. (2003) [Pubmed]
  11. Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus. Hirschberg, C.B., Robbins, P.W., Abeijon, C. Annu. Rev. Biochem. (1998) [Pubmed]
  12. Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus. Hirschberg, C.B., Snider, M.D. Annu. Rev. Biochem. (1987) [Pubmed]
  13. Prolonged survival in three brothers with severe type 2 Crigler-Najjar syndrome. Ultrastructural and metabolic studies. Gollan, J.L., Huang, S.N., Billing, B., Sherlock, S. Gastroenterology (1975) [Pubmed]
  14. Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1. Campadelli, G., Brandimarti, R., Di Lazzaro, C., Ward, P.L., Roizman, B., Torrisi, M.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  15. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. Charest, A., Kheifets, V., Park, J., Lane, K., McMahon, K., Nutt, C.L., Housman, D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus. Rosenberg, N., Yatuv, R., Sobolev, V., Peretz, H., Zivelin, A., Seligsohn, U. Blood (2003) [Pubmed]
  17. Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis (ALS). Clinical studies in ALS of Guam and experimental studies in deafferented neurons and in beta,beta'-iminodipropionitrile axonopathy. Mourelatos, Z., Hirano, A., Rosenquist, A.C., Gonatas, N.K. Am. J. Pathol. (1994) [Pubmed]
  18. A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. Ahn, J., Febbraio, M., Silverstein, R.L. J. Cell. Sci. (2005) [Pubmed]
  19. The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Steegmaier, M., Levinovitz, A., Isenmann, S., Borges, E., Lenter, M., Kocher, H.P., Kleuser, B., Vestweber, D. Nature (1995) [Pubmed]
  20. Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1. Wild, M.K., Huang, M.C., Schulze-Horsel, U., van der Merwe, P.A., Vestweber, D. J. Biol. Chem. (2001) [Pubmed]
  21. Expression of sialyl-Lewis X, an E-selectin ligand, in inflammation, immune processes, and lymphoid tissues. Munro, J.M., Lo, S.K., Corless, C., Robertson, M.J., Lee, N.C., Barnhill, R.L., Weinberg, D.S., Bevilacqua, M.P. Am. J. Pathol. (1992) [Pubmed]
  22. Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Kalra, J., Shao, Q., Qin, H., Thomas, T., Alaoui-Jamali, M.A., Laird, D.W. Carcinogenesis (2006) [Pubmed]
  23. A single amino acid residue can determine the ligand specificity of E-selectin. Kogan, T.P., Revelle, B.M., Tapp, S., Scott, D., Beck, P.J. J. Biol. Chem. (1995) [Pubmed]
  24. The rate of bulk flow from the Golgi to the plasma membrane. Karrenbauer, A., Jeckel, D., Just, W., Birk, R., Schmidt, R.R., Rothman, J.E., Wieland, F.T. Cell (1990) [Pubmed]
  25. Monensin inhibits initial spreading of cultured human fibroblasts. Pizzey, J.A., Bennett, F.A., Jones, G.E. Nature (1983) [Pubmed]
  26. Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells. Scheffers, M.S., Le, H., van der Bent, P., Leonhard, W., Prins, F., Spruit, L., Breuning, M.H., de Heer, E., Peters, D.J. Hum. Mol. Genet. (2002) [Pubmed]
  27. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. Spasic, D., Tolia, A., Dillen, K., Baert, V., De Strooper, B., Vrijens, S., Annaert, W. J. Biol. Chem. (2006) [Pubmed]
  28. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. Laitinen, S., Olkkonen, V.M., Ehnholm, C., Ikonen, E. J. Lipid Res. (1999) [Pubmed]
  29. Different concentrations of thyroid peroxidase and thyroglobulin in the nuclear envelope and the endoplasmic reticulum throughout the cytoplasm. Zimmer, K.P., Hengst, K., Carayon, P., Brämswig, J., Harms, E. Eur. J. Cell Biol. (1992) [Pubmed]
  30. Maturation of lipoprotein lipase in the endoplasmic reticulum. Concurrent formation of functional dimers and inactive aggregates. Ben-Zeev, O., Mao, H.Z., Doolittle, M.H. J. Biol. Chem. (2002) [Pubmed]
  31. Screening a series of sialyltransferases for possible BACE1 substrates. Kitazume, S., Tachida, Y., Oka, R., Nakagawa, K., Takashima, S., Lee, Y.C., Hashimoto, Y. Glycoconj. J. (2006) [Pubmed]
  32. Sex differences in estrogen receptor alpha and beta expression in vasopressin neurons of the supraoptic nucleus in elderly and Alzheimer's disease patients: no relationship with cytoskeletal alterations. Ishunina, T.A., Wouda, J., Fisser, B., Swaab, D.F. Brain Res. (2002) [Pubmed]
  33. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) regulates endothelial nitric oxide synthase (eNOS) activity and its localization within the human vein endothelial cells (HUVEC) in culture. Di Pietro, R., Mariggiò, M.A., Guarnieri, S., Sancilio, S., Giardinelli, A., Di Silvestre, S., Consoli, A., Zauli, G., Pandolfi, A. J. Cell. Biochem. (2006) [Pubmed]
  34. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase. Bennett, B.D., Denis, P., Haniu, M., Teplow, D.B., Kahn, S., Louis, J.C., Citron, M., Vassar, R. J. Biol. Chem. (2000) [Pubmed]
  35. A novel recently evolved gene C19orf24 encodes a non-classical secreted protein. Wang, X.R., Zhou, Y.B., Liu, F., Wang, K.S., Shen, Y., Liu, J.H., Han, Z.G. Cell. Mol. Biol. Lett. (2006) [Pubmed]
  36. Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation. Smart, E.J., Ying, Y.S., Conrad, P.A., Anderson, R.G. J. Cell Biol. (1994) [Pubmed]
  37. Paranuaclear E-cadherin in gastric adenocarcinoma. Carpenter, P.M., Al-Kuran, R.A., Theuer, C.P. Am. J. Clin. Pathol. (2002) [Pubmed]
  38. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. Franco, M., Boretto, J., Robineau, S., Monier, S., Goud, B., Chardin, P., Chavrier, P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  39. Trafficking and activation of eNOS in epithelial cells. Ortiz, P.A., Garvin, J.L. Acta Physiol. Scand. (2003) [Pubmed]
  40. The LPS receptor generates inflammatory signals from the cell surface. Latz, E., Visintin, A., Lien, E., Fitzgerald, K.A., Espevik, T., Golenbock, D.T. J. Endotoxin Res. (2003) [Pubmed]
  41. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. Chen, C., Li, J.G., Chen, Y., Huang, P., Wang, Y., Liu-Chen, L.Y. J. Biol. Chem. (2006) [Pubmed]
  42. ApoE epsilon4 genotype is accompanied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. Dubelaar, E.J., Verwer, R.W., Hofman, M.A., Van Heerikhuize, J.J., Ravid, R., Swaab, D.E. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  43. Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Litvak, V., Argov, R., Dahan, N., Ramachandran, S., Amarilio, R., Shainskaya, A., Lev, S. Mol. Cell (2004) [Pubmed]
  44. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. Dimitroff, C.J., Lee, J.Y., Rafii, S., Fuhlbrigge, R.C., Sackstein, R. J. Cell Biol. (2001) [Pubmed]
  45. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Kitazume, S., Tachida, Y., Oka, R., Shirotani, K., Saido, T.C., Hashimoto, Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  46. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. Mourelatos, Z., Gonatas, J.O., Cinato, E., Gonatas, N.K. DNA Cell Biol. (1996) [Pubmed]
  47. A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. Young, S.G., Cham, C.M., Pitas, R.E., Burri, B.J., Connolly, A., Flynn, L., Pappu, A.S., Wong, J.S., Hamilton, R.L., Farese, R.V. J. Clin. Invest. (1995) [Pubmed]
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