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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effect of the JAK2 V617F mutation on PRV-1 expression.

JAK2(V617F)an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2(V617F) on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2(V617F) increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F- induced increase in PRV-1 expression.[1]

References

  1. The effect of the JAK2 V617F mutation on PRV-1 expression. Mnjoyan, Z., Yoon, D., Li, J., Delhommeau, F., Afshar-Kharghan, V. Haematologica (2006) [Pubmed]
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