The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CD177  -  CD177 molecule

Homo sapiens

Synonyms: CD177 antigen, HNA-2a, HNA2A, Human neutrophil alloantigen 2a, NB1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CD177


High impact information on CD177


Chemical compound and disease context of CD177


Biological context of CD177


Anatomical context of CD177


Associations of CD177 with chemical compounds

  • HNA-2 antigens are located on 58- to 64-Kd glycoprotein, CD177, and are encoded by a gene on chromosome 19 that belongs to the Ly-6 family [20].
  • PRV-1 is a member of the uPAR/CD59/Ly6 family of cell surface receptors, which share a common cysteine-rich domain and are tethered to the cell surface via a glycosylphosphatidylinositol (GPI) link [21].
  • When neutrophils were stimulated with C5a, PMA, or FMLP, no differences were found in the adhesion of NB1-positive and NB1-negative cells to the same surfaces [22].
  • A patient with polycythemia rubra vera had had a leukocyte count between 55,000 and 86,000/cu mm and had had serum glucose levels as low as 8 mg/dL [23].
  • Surface expression of the NB1 antigen was slightly up-regulated by treatment with the chemotactic peptide f-met-leu-phe [24].

Regulatory relationships of CD177


Other interactions of CD177

  • The cycle threshold (CT) value of PRV-1 was determined and was divided with the CT value for the housekeeping GAPDH gene transcript [28].
  • Interestingly, decreased c-MPL and elevated PRV-1 also were observed in patients with hereditary thrombocythemia (HT) who carry a mutation in the thrombopoietin (TPO) gene [29].
  • Decreased expression of c-MPL protein in platelets, increased expression of polycythemia rubra vera 1 (PRV-1) and nuclear factor I-B (NFIB) mRNA in granulocytes, and loss of heterozygosity on chromosome 9p (9pLOH) were described as molecular markers for myeloproliferative disorders (MPDs) [29].
  • Patients with PV who were homozygous or heterozygous for JAK2-V617F exhibited higher levels of expression of the 13 new markers, PRV1, and NF-E2 than patients without JAK2-V617F, whereas ANKRD15 was down-regulated in these patients [30].
  • The 30 ET patients who had not received any platelet lowering treatment showed a significant (P = 0.005) relation between PRV-1 positivity and subnormal plasma EPO [28].

Analytical, diagnostic and therapeutic context of CD177


  1. The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients. Goerttler, P.S., Steimle, C., März, E., Johansson, P.L., Andreasson, B., Griesshammer, M., Gisslinger, H., Heimpel, H., Pahl, H.L. Blood (2005) [Pubmed]
  2. Neutrophil CD177 (NB1 gp, HNA-2a) expression is increased in severe bacterial infections and polycythaemia vera. Göhring, K., Wolff, J., Doppl, W., Schmidt, K.L., Fenchel, K., Pralle, H., Sibelius, U., Bux, J. Br. J. Haematol. (2004) [Pubmed]
  3. Molecular basis of NB1 (HNA-2a, CD177) deficiency. Kissel, K., Scheffler, S., Kerowgan, M., Bux, J. Blood (2002) [Pubmed]
  4. Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. Temerinac, S., Klippel, S., Strunck, E., Röder, S., Lübbert, M., Lange, W., Azemar, M., Meinhardt, G., Schaefer, H.E., Pahl, H.L. Blood (2000) [Pubmed]
  5. Determination of serum immunoreactive erythropoietin in the investigation of erythrocytosis. Cotes, P.M., Doré, C.J., Yin, J.A., Lewis, S.M., Messinezy, M., Pearson, T.C., Reid, C. N. Engl. J. Med. (1986) [Pubmed]
  6. X-linked somatic-cell selection and polycythemia rubra vera. Williams, C.K., Esan, G.J., Luzzatto, L., Town, M.M., Ogunmola, G.B. N. Engl. J. Med. (1984) [Pubmed]
  7. Polycythemia rubra vera progressing to Ph1-positive chronic myelogenous leukemia. Hoppin, E.C., Lewis, J.P. Ann. Intern. Med. (1975) [Pubmed]
  8. Smoking as a cause of erythrocytosis. Sagone, A.L., Balcerzak, S.P. Ann. Intern. Med. (1975) [Pubmed]
  9. Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions. Kissel, K., Santoso, S., Hofmann, C., Stroncek, D., Bux, J. Eur. J. Immunol. (2001) [Pubmed]
  10. Cellular pharmacokinetics of carboplatin and cisplatin in relation to their cytotoxic action. Los, G., Verdegaal, E., Noteborn, H.P., Ruevekamp, M., de Graeff, A., Meesters, E.W., ten Bokkel Huinink, D., McVie, J.G. Biochem. Pharmacol. (1991) [Pubmed]
  11. Platelet-rich plasma serotonin levels in chronic myeloproliferative disorders: evaluation of diagnostic use and comparison with the neutrophil PRV-1 assay. Koch, C.A., Lasho, T.L., Tefferi, A. Br. J. Haematol. (2004) [Pubmed]
  12. Aquagenic pruritus. Water-induced activation of acetylcholinesterase. Bircher, A.J., Meier-Ruge, W. Archives of dermatology. (1988) [Pubmed]
  13. Eosinophilic leukemic transformation in polycythemia rubra vera (PRV). Chim, C.S., Ma, S.K. Leuk. Lymphoma (2005) [Pubmed]
  14. CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression. Caruccio, L., Walkovich, K., Bettinotti, M., Schuller, R., Stroncek, D. Transfusion (2004) [Pubmed]
  15. Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology. Stroncek, D. Vox Sang. (2002) [Pubmed]
  16. Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders. Kralovics, R., Skoda, R.C. Blood Rev. (2005) [Pubmed]
  17. Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. Bauer, S., Abdgawad, M., Gunnarsson, L., Segelmark, M., Tapper, H., Hellmark, T. J. Leukoc. Biol. (2007) [Pubmed]
  18. The gene overexpressed in polycythemia rubra vera, PRV-1, and the gene encoding a neutrophil alloantigen, NB1, are alleles of a single gene, CD177, in chromosome band 19q13.31. Caruccio, L., Bettinotti, M., Director-Myska, A.E., Arthur, D.C., Stroncek, D. Transfusion (2006) [Pubmed]
  19. Clinical significance of neutrophil CD177 mRNA expression in Ph-negative chronic myeloproliferative disorders. Passamonti, F., Pietra, D., Malabarba, L., Rumi, E., Della Porta, M.G., Malcovati, L., Bonfichi, M., Pascutto, C., Lazzarino, M., Cazzola, M. Br. J. Haematol. (2004) [Pubmed]
  20. Neutrophil alloantigens. Stroncek, D. Transfusion medicine reviews. (2002) [Pubmed]
  21. Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. Klippel, S., Strunck, E., Busse, C.E., Behringer, D., Pahl, H.L. Blood (2002) [Pubmed]
  22. Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions. Stroncek, D.F., Herr, G.P., Plachta, L.B. J. Lab. Clin. Med. (1994) [Pubmed]
  23. Polycythemia rubra vera and artifactual hypoglycemia. Arem, R., Jeang, M.K., Blevens, T.C., Waddell, C.C., Field, J.B. Arch. Intern. Med. (1982) [Pubmed]
  24. Neutrophil-specific antigen NB1 is anchored via a glycosyl-phosphatidylinositol linkage. Skubitz, K.M., Stroncek, D.F., Sun, B. J. Leukoc. Biol. (1991) [Pubmed]
  25. The effect of the JAK2 V617F mutation on PRV-1 expression. Mnjoyan, Z., Yoon, D., Li, J., Delhommeau, F., Afshar-Kharghan, V. Haematologica (2006) [Pubmed]
  26. Quantitative real-time polymerase chain reaction shows that treatment with interferon reduces the initially upregulated PRV-1 expression in polycythemia vera patients. Fruehauf, S., Topaly, J., Villalobos, M., Veldwijk, M.R., Laufs, S., Ho, A.D. Haematologica (2003) [Pubmed]
  27. The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). Sachs, U.J., Andrei-Selmer, C.L., Maniar, A., Weiss, T., Paddock, C., Orlova, V.V., Choi, E.Y., Newman, P.J., Preissner, K.T., Chavakis, T., Santoso, S. J. Biol. Chem. (2007) [Pubmed]
  28. The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia. Johansson, P., Andréasson, B., Safai-Kutti, S., Wennström, L., Palmqvist, L., Ricksten, A., Lindstedt, G., Kutti, J. Eur. J. Haematol. (2003) [Pubmed]
  29. Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. Kralovics, R., Buser, A.S., Teo, S.S., Coers, J., Tichelli, A., van der Maas, A.P., Skoda, R.C. Blood (2003) [Pubmed]
  30. Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2. Kralovics, R., Teo, S.S., Buser, A.S., Brutsche, M., Tiedt, R., Tichelli, A., Passamonti, F., Pietra, D., Cazzola, M., Skoda, R.C. Blood (2005) [Pubmed]
  31. Assessment of the relative number of copies of the gene encoding human neutrophil antigen-2a(HNA-2a), CD177, and a homologous pseudogene by quantitative real-time PCR. Dittmar, K., Lim, J.B., Caruccio, L., Bettinotti, M., Stroncek, D. Immunohematology / American Red Cross. (2003) [Pubmed]
  32. Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms. Wolff, J., Brendel, C., Fink, L., Bohle, R.M., Kissel, K., Bux, J. Blood (2003) [Pubmed]
  33. Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis. Najfeld, V., Fuchs, S., Merando, P., Lezon-Geyda, K., Fruchtman, S. Exp. Hematol. (2003) [Pubmed]
  34. Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia. Martini, M., Teofili, L., Larocca, L.M. Methods Mol. Med. (2006) [Pubmed]
WikiGenes - Universities