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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases.

To evaluate the activity of posaconazole for treatment of zygomycosis, a disease for which therapeutic options are limited, we conducted a retrospective study including 91 patients with zygomycosis (proven zygomycosis, 69 patients; probable zygomycosis, 22 patients). Patients had infection that was refractory to prior antifungal treatment (n=81) or were intolerant of such treatment (n=10) and participated in the compassionate-use posaconazole (800 mg/day) program. The rate of success (i.e., either complete or partial response) at 12 weeks after treatment initiation was 60%, and 21% of patients had stable disease. The overall high success and survival rates reported here provide encouraging data regarding posaconazole as an alternative therapy for zygomycosis.[1]

References

  1. Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. van Burik, J.A., Hare, R.S., Solomon, H.F., Corrado, M.L., Kontoyiannis, D.P. Clin. Infect. Dis. (2006) [Pubmed]
 
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