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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila.

The maleless (mle) gene is one of four known regulatory loci required for increased transcription ( dosage compensation) of X-linked genes in D. melanogaster males. A predicted mle protein (MLE) contains seven short segments that define a superfamily of known and putative RNA and DNA helicases. MLE, while present in the nuclei of both male and female cells, differs in its association with polytene X chromosomes in the two sexes. MLE is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females. The predominant localization of MLE to the X chromosome in males makes it a strong candidate to be a direct regulator of dosage compensation.[1]

References

  1. The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Kuroda, M.I., Kernan, M.J., Kreber, R., Ganetzky, B., Baker, B.S. Cell (1991) [Pubmed]
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