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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

An altered neonatal behavioral phenotype in Mecp2 mutant mice.

We examined somatic growth, somatosensory reflexes, and ultrasonic calls from postnatal day 3 to day 18 in Mecp2 mutant mice, a mouse model of Rett syndrome. Both Mecp2 null male and Mecp2 heterozygous female mice exhibited normal somatic growth, but transient delays in the development of some reflexes relative to sex-matched wild-type mice. Both Mecp2 null male and heterozygous female mice exhibited dramatic increases in ultrasonic vocalizations in response to social isolation; these differences were evident as early as postnatal day 5. These results suggest very early abnormalities in sensory reflex development and behavioral responsiveness in the Mecp2 mutants that may provide a target for early therapeutic intervention.[1]


  1. An altered neonatal behavioral phenotype in Mecp2 mutant mice. Picker, J.D., Yang, R., Ricceri, L., Berger-Sweeney, J. Neuroreport (2006) [Pubmed]
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