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MeSH Review

Social Isolation

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Disease relevance of Social Isolation


Psychiatry related information on Social Isolation


High impact information on Social Isolation

  • These data suggest that a switch (a decrease in alpha1/alpha2 and gamma2 and an increase in alpha4 and alpha5 subunits) in the composition of the heteropentameric GABA(A)-R subunit assembly without a change in total GABA(A)-R number occurs during social isolation [4].
  • Infant Oxtr(-/-) males emitted fewer ultrasonic vocalizations than wild-type littermates in response to social isolation [9].
  • Fluoxetine (FLX) and norfluoxetine (NFLX) stereospecifically reverse the effect of social isolation on the PTB-induced loss of righting reflex and on the decrease of telencephalic Allo content [10].
  • Protracted social isolation in mice may provide a model to investigate whether 5alpha-DHP by a genomic action, and ALLO by a nongenomic mechanism down-regulate the action of drugs acting as agonists, partial agonists, or positive allosteric modulators of the benzodiazepine recognition sites expressed by GABA(A) receptors [11].
  • Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation [11].

Chemical compound and disease context of Social Isolation


Biological context of Social Isolation


Anatomical context of Social Isolation


Associations of Social Isolation with chemical compounds

  • These results suggest that mild chronic stress, such as that induced by social isolation, enhances the steroidogenic effect of ethanol, a drug abused by humans under stress or affected by neuropsychiatric disorders [25].
  • The data are discussed with respect to the involvement of ventral striatal DA mechanisms in the expression of PPI and LI, differences in the impact of social isolation in young and adult animals, and the utility of social isolation model as a nonlesion, nonpharmacologic means of perturbing ventral striatal DA function [26].
  • Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration [25].
  • The effects of social isolation on behavior, neuroactive steroid concentrations, and GABA(A) receptor function were investigated in rats [27].
  • Effects of social isolation on pentobarbital activity in mice: relationship to racemate levels and enantiomer levels in brain [28].

Gene context of Social Isolation

  • Both Mecp2 null male and heterozygous female mice exhibited dramatic increases in ultrasonic vocalizations in response to social isolation; these differences were evident as early as postnatal day 5 [29].
  • The above data suggest that the social isolation stress augmented the tumor-induced angiogenesis probably by up-regulating the angiogenesis-related factors, including TNF-alpha, VEGF and HGF, and consequently mediating the functions of endothelial cells such as migration, invasion, and tube-like formation [30].
  • In this study, we have investigated whether a prolonged period of partial social isolation can modify central brain-derived neurotrophic (BDNF) concentrations [6].
  • Social isolation induces preference for odours of oestrous females in sexually naive male staggerer mutant mice [31].
  • Autoradiographic analyses of 5-HT1A and 5-HT2A receptors after social isolation in mice [32].

Analytical, diagnostic and therapeutic context of Social Isolation


  1. Effects of postnatal social isolation on hormonal and immune responses of pigs to an acute endotoxin challenge. Tuchscherer, M., Kanitz, E., Puppe, B., Tuchscherer, A., Stabenow, B. Physiol. Behav. (2004) [Pubmed]
  2. Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress. Wu, W., Yamaura, T., Murakami, K., Ogasawara, M., Hayashi, K., Murata, J., Saiki, I. Oncol. Res. (1999) [Pubmed]
  3. The influence of social isolation, hypoxia and immobilization on potassium-stimulated dopamine release from telencephalon slices of mice. Wustmann, C., Oehler, J., Dienel, A., Jähkel, M., Fischer, H.D., Schmidt, J. Biomed. Biochim. Acta (1987) [Pubmed]
  4. Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Pinna, G., Agis-Balboa, R.C., Zhubi, A., Matsumoto, K., Grayson, D.R., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Effects of diazepam, citalopram, methadone and naloxone on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test. Sams-Dodd, F. Neuroscience and biobehavioral reviews. (1998) [Pubmed]
  6. Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone. Scaccianoce, S., Del Bianco, P., Paolone, G., Caprioli, D., Modafferi, A.M., Nencini, P., Badiani, A. Behav. Brain Res. (2006) [Pubmed]
  7. Comparison of the effects of dopamine agonists on self-stimulation of the hypothalamus with lesioning of mesolimbic brain structures in rats reared in conditions of social isolation. Panchenko, G.N., Lebedev, A.A., Shabanov, P.D. Neurosci. Behav. Physiol. (1998) [Pubmed]
  8. Psychosocial factors related to perceived compliance with cystic fibrosis treatment. Geiss, S.K., Hobbs, S.A., Hammersley-Maercklein, G., Kramer, J.C., Henley, M. Journal of clinical psychology. (1992) [Pubmed]
  9. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Takayanagi, Y., Yoshida, M., Bielsky, I.F., Ross, H.E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M.M., Young, L.J., Nishimori, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Pinna, G., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Dong, E., Matsumoto, K., Uzunova, V., Sugaya, I., Takahata, H., Nomura, H., Watanabe, H., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  12. Social isolation-induced enhancement of the psychomotor effects of morphine depends on corticosterone secretion. Deroche, V., Piazza, P.V., Le Moal, M., Simon, H. Brain Res. (1994) [Pubmed]
  13. Effect of novel antipsychotic drugs on phencyclidine-induced stereotyped behaviour and social isolation in the rat social interaction test. Sams-Dodd, F. Behavioural pharmacology. (1997) [Pubmed]
  14. Lack of effect of exercise training on dehydroepiandrosterone-sulfate. Milani, R.V., Lavie, C.J., Barbee, R.W., Littman, A.B. Am. J. Med. Sci. (1995) [Pubmed]
  15. In adolescence, female rats are more sensitive to the anxiolytic effect of nicotine than are male rats. Cheeta, S., Irvine, E.E., Tucci, S., Sandhu, J., File, S.E. Neuropsychopharmacology (2001) [Pubmed]
  16. Social isolation after a single defeat reduces striatal dopamine transporter binding in rats. Isovich, E., Engelmann, M., Landgraf, R., Fuchs, E. Eur. J. Neurosci. (2001) [Pubmed]
  17. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Barrientos, R.M., Sprunger, D.B., Campeau, S., Higgins, E.A., Watkins, L.R., Rudy, J.W., Maier, S.F. Neuroscience (2003) [Pubmed]
  18. Effect of isolation on dopaminergic agonist-induced penile erections and stretching and yawning in male rats. Ferrari, F., Mangiafico, V. Behav. Brain Res. (1988) [Pubmed]
  19. Social isolation stress-induced oxidative damage in mouse brain and its modulation by majonoside-R2, a Vietnamese ginseng saponin. Huong, N.T., Murakami, Y., Tohda, M., Watanabe, H., Matsumoto, K. Biol. Pharm. Bull. (2005) [Pubmed]
  20. Social isolation does not alter brain regional benzodiazepine binding site numbers, affinity and coupling in the rat. Morinan, A., Parker, V., Rich, D.A., Cariuk, P., Horton, R.W. Psychopharmacology (Berl.) (1992) [Pubmed]
  21. Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat. Fulford, A.J., Marsden, C.A. Neuroscience (1998) [Pubmed]
  22. Role of V1a vasopressin receptors in the control of aggression in Syrian hamsters. Albers, H.E., Dean, A., Karom, M.C., Smith, D., Huhman, K.L. Brain Res. (2006) [Pubmed]
  23. Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses. Kanitz, E., Tuchscherer, M., Puppe, B., Tuchscherer, A., Stabenow, B. Brain Behav. Immun. (2004) [Pubmed]
  24. Central corticotropin-releasing factor and benzodiazepine receptor systems are involved in the social isolation stress-induced decrease in ethanol sleep in mice. Matsumoto, K., Ojima, K., Watanabe, H. Brain Res. (1997) [Pubmed]
  25. Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol. Serra, M., Pisu, M.G., Floris, I., Cara, V., Purdy, R.H., Biggio, G. J. Neurochem. (2003) [Pubmed]
  26. Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Wilkinson, L.S., Killcross, S.S., Humby, T., Hall, F.S., Geyer, M.A., Robbins, T.W. Neuropsychopharmacology (1994) [Pubmed]
  27. Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain. Serra, M., Pisu, M.G., Littera, M., Papi, G., Sanna, E., Tuveri, F., Usala, L., Purdy, R.H., Biggio, G. J. Neurochem. (2000) [Pubmed]
  28. Effects of social isolation on pentobarbital activity in mice: relationship to racemate levels and enantiomer levels in brain. Watanabe, H., Ohdo, S., Ishikawa, M., Ogawa, N. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  29. An altered neonatal behavioral phenotype in Mecp2 mutant mice. Picker, J.D., Yang, R., Ricceri, L., Berger-Sweeney, J. Neuroreport (2006) [Pubmed]
  30. Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice. Wu, W., Murata, J., Murakami, K., Yamaura, T., Hayashi, K., Saiki, I. Clin. Exp. Metastasis (2000) [Pubmed]
  31. Social isolation induces preference for odours of oestrous females in sexually naive male staggerer mutant mice. Féron, C., Baudoin, C. Chem. Senses (1998) [Pubmed]
  32. Autoradiographic analyses of 5-HT1A and 5-HT2A receptors after social isolation in mice. Schiller, L., Jähkel, M., Kretzschmar, M., Brust, P., Oehler, J. Brain Res. (2003) [Pubmed]
  33. Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice. Matsumoto, K., Ojima, K., Watanabe, H. Brain Res. (1996) [Pubmed]
  34. Effects of a short-term health promotion intervention for a predominantly African-American group of stroke survivors. Rimmer, J.H., Braunschweig, C., Silverman, K., Riley, B., Creviston, T., Nicola, T. American journal of preventive medicine. (2000) [Pubmed]
  35. Estrogen replacement in perimenopause-related depression: a preliminary report. Schmidt, P.J., Nieman, L., Danaceau, M.A., Tobin, M.B., Roca, C.A., Murphy, J.H., Rubinow, D.R. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  36. Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice. Yamada, K., Ohki-Hamazaki, H., Wada, K. Physiol. Behav. (2000) [Pubmed]
  37. Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress. Filipović, D., Gavrilović, L., Dronjak, S., Radojcić, M.B. Neuropsychobiology (2005) [Pubmed]
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