Cellular factors required for Lassa virus budding.
It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.[1]References
- Cellular factors required for Lassa virus budding. Urata, S., Noda, T., Kawaoka, Y., Yokosawa, H., Yasuda, J. J. Virol. (2006) [Pubmed]
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