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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Lassa Virus

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Disease relevance of Lassa Virus


High impact information on Lassa Virus

  • The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P [3].
  • We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally [6].
  • The degree of IFN sensitivity of a Lassa virus isolate did not correlate with disease severity in human patients [4].
  • Three low-passage Lassa virus strains (AV, NL, and CSF), isolated from humans with mild to fulminant Lassa fever, were tested [4].
  • Lassa virus is an enveloped virus with glycoprotein spikes on its surface [7].

Chemical compound and disease context of Lassa Virus


Biological context of Lassa Virus


Anatomical context of Lassa Virus

  • This report shows for the first time that seropositive individuals from areas of endemicity have very strong memory CD4(+) T-cell responses against the NP of Lassa virus, which are partly strain specific and partly cross-reactive with other Lassa virus strains [5].
  • Fractionated RNAs were translated in rabbit reticulocyte lysates, and translation products were precipitated with monoclonal antibodies to the nucleocapsid protein of Lassa virus [17].

Gene context of Lassa Virus

  • Comparison of full-length gene sequences for four Lassa virus strains representing the four lineages showed that the NP gene (up to 23.8% nucleotide difference and 12.0% amino acid difference) is more variable than the glycoprotein genes [18].
  • Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected] [7].
  • However, difficulties have been encountered in using the PRNT for LCM virus, while conflicting views have been expressed about the reliability and efficacy of the test with Lassa virus [11].
  • Lassa virus is the causative agent of a hemorrhagic fever endemic in west Africa. The RNA genome of Lassa virus encodes the glycoprotein precursor GP-C, a nucleoprotein (NP), the viral polymerase L and a small protein Z (11 kDa) [19].
  • Comparison of SKI-1 cleavage efficiency between peptides representing Lassa virus GP2 and CCHF virus Gn cleavage sites suggests that amino acids flanking the RRLL may modulate the efficiency [20].

Analytical, diagnostic and therapeutic context of Lassa Virus


  1. Vaccinia recombinant expressing Lassa-virus internal nucleocapsid protein protects guineapigs against Lassa fever. Clegg, J.C., Lloyd, G. Lancet (1987) [Pubmed]
  2. Protection of rhesus monkeys from fatal Lassa fever by vaccination with a recombinant vaccinia virus containing the Lassa virus glycoprotein gene. Fisher-Hoch, S.P., McCormick, J.B., Auperin, D., Brown, B.G., Castor, M., Perez, G., Ruo, S., Conaty, A., Brammer, L., Bauer, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Lenz, O., ter Meulen, J., Klenk, H.D., Seidah, N.G., Garten, W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus. Asper, M., Sternsdorf, T., Hass, M., Drosten, C., Rhode, A., Schmitz, H., Günther, S. J. Virol. (2004) [Pubmed]
  5. Characterization of human CD4(+) T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein. ter Meulen, J., Badusche, M., Kuhnt, K., Doetze, A., Satoguina, J., Marti, T., Loeliger, C., Koulemou, K., Koivogui, L., Schmitz, H., Fleischer, B., Hoerauf, A. J. Virol. (2000) [Pubmed]
  6. Cellular factors required for Lassa virus budding. Urata, S., Noda, T., Kawaoka, Y., Yokosawa, H., Yasuda, J. J. Virol. (2006) [Pubmed]
  7. Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected]. Strecker, T., Eichler, R., Meulen, J., Weissenhorn, W., Dieter Klenk, H., Garten, W., Lenz, O. J. Virol. (2003) [Pubmed]
  8. Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin. Jahrling, P.B., Hesse, R.A., Eddy, G.A., Johnson, K.M., Callis, R.T., Stephen, E.L. J. Infect. Dis. (1980) [Pubmed]
  9. Structural and cell-associated proteins of Lassa virus. Clegg, J.C., Lloyd, G. J. Gen. Virol. (1983) [Pubmed]
  10. Detection of Lassa virus antinucleoprotein immunoglobulin G (IgG) and IgM antibodies by a simple recombinant immunoblot assay for field use. Ter Meulen, J., Koulemou, K., Wittekindt, T., Windisch, K., Strigl, S., Conde, S., Schmitz, H. J. Clin. Microbiol. (1998) [Pubmed]
  11. Standardization of a plaque assay for Lassa virus. Tomori, O., Johnson, K.M., Kiley, M.P., Elliott, L.H. J. Med. Virol. (1987) [Pubmed]
  12. Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro. Günther, S., Asper, M., Röser, C., Luna, L.K., Drosten, C., Becker-Ziaja, B., Borowski, P., Chen, H.M., Hosmane, R.S. Antiviral Res. (2004) [Pubmed]
  13. Identification of a novel consensus sequence at the cleavage site of the Lassa virus glycoprotein. Lenz, O., ter Meulen, J., Feldmann, H., Klenk, H.D., Garten, W. J. Virol. (2000) [Pubmed]
  14. Expression of the Lassa virus nucleocapsid protein in insect cells infected with a recombinant baculovirus: application to diagnostic assays for Lassa virus infection. Barber, G.N., Clegg, J.C., Lloyd, G. J. Gen. Virol. (1990) [Pubmed]
  15. Molecular cloning of Lassa virus RNA: nucleotide sequence and expression of the nucleocapsid protein gene. Clegg, J.C., Oram, J.D. Virology (1985) [Pubmed]
  16. Sequence analysis of the S RNA of the African arenavirus Mopeia: an unusual secondary structure feature in the intergenic region. Wilson, S.M., Clegg, J.C. Virology (1991) [Pubmed]
  17. Identification of messenger RNA for nucleocapsid protein of Lassa virus in infected cells. Lukashevich, I.S., Stelmakh, T.A., Stchesljenok, E.P., Shkolina, T.V. Intervirology (1988) [Pubmed]
  18. Genetic diversity among Lassa virus strains. Bowen, M.D., Rollin, P.E., Ksiazek, T.G., Hustad, H.L., Bausch, D.G., Demby, A.H., Bajani, M.D., Peters, C.J., Nichol, S.T. J. Virol. (2000) [Pubmed]
  19. Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP). Eichler, R., Strecker, T., Kolesnikova, L., ter Meulen, J., Weissenhorn, W., Becker, S., Klenk, H.D., Garten, W., Lenz, O. Virus Res. (2004) [Pubmed]
  20. Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. Vincent, M.J., Sanchez, A.J., Erickson, B.R., Basak, A., Chretien, M., Seidah, N.G., Nichol, S.T. J. Virol. (2003) [Pubmed]
  21. Lassa virus activity in Guinea: distribution of human antiviral antibody defined using enzyme-linked immunosorbent assay with recombinant antigen. Lukashevich, L.S., Clegg, J.C., Sidibe, K. J. Med. Virol. (1993) [Pubmed]
  22. Epitope mapping of the Lassa virus nucleoprotein using monoclonal anti-nucleocapsid antibodies. Hufert, F.T., Lüdke, W., Schmitz, H. Arch. Virol. (1989) [Pubmed]
  23. Construction of a recombinant vaccinia virus expressing the Lassa virus glycoprotein gene and protection of guinea pigs from a lethal Lassa virus infection. Auperin, D.D., Esposito, J.J., Lange, J.V., Bauer, S.P., Knight, J., Sasso, D.R., McCormick, J.B. Virus Res. (1988) [Pubmed]
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