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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Synthesis of a biotin-derived alkyne for pd-catalyzed coupling reactions.

An efficient synthesis of a terminal alkyne derived from d-biotin was developed to provide an alternative for carboxyl-based biotinylation. This approach was illustrated by the preparation of alkyne- and alkene-linked phenylalanine derivatives using palladium-catalyzed Sonogashira and Oh methodology. (Strept)avidin binding was observed using soluble and immobilized receptors. These results demonstrate the applicability of carbon-linked biotin derivatives for use in affinity-based purification and bioanalytical applications.[1]

References

  1. Synthesis of a biotin-derived alkyne for pd-catalyzed coupling reactions. Corona, C., Bryant, B.K., Arterburn, J.B. Org. Lett. (2006) [Pubmed]
 
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