The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Biotin(V-H)     5-(7-oxo-3-thia-6,8- diazabicyclo[3.3.0]oct...

Synonyms: AC-124, AG-A-80102, BSPBio_002329, KBioGR_001382, KBioSS_000705, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of vitamin H

  • We demonstrate here that endodermal sinus tumour cells, but not other cell types isolated from testicular teratomas, secrete the serum attachment protein, vitronectin (also known as serum-spreading factor, S-protein or epibolin), as well as fibronectin, laminin and type IV collagen, into serum-free medium [1].
  • Because restoration of pimaricin production in the npi287 mutant is conferred by both A-factor and PI factor, S. natalensis appears to be able to integrate different quorum signals from actinomycetes [2].
  • Membranes containing permease with the biotin acceptor domain from the Klebsiella pneumoniae oxaloacetate decarboxylase are extracted with 5 M urea or treated with dicyclohexylcarbodiimide to inactivate F1/Fo ATPase and biotinylated in vitro with biotin ligase, ATP and d-biotin [3].
  • Rhodobacter sphaeroides f. sp. denitrificans biotin sulfoxide reductase (BSOR) catalyzes the reduction of d-biotin d-sulfoxide to biotin and contains the molybdopterin guanine dinucleotide (MGD) cofactor as its sole prosthetic group [4].
  • With the parameters (such as k1, k2, growth rate constant kG, critical concentration of HOCs in the organism resulting in growth inhibition CA* and spread factor S) the variability in toxicity (such as EC10, EC50, EC70) can be estimated from the combined bioconcentration and probability model, which fits well with the experimental observations [5].

Psychiatry related information on vitamin H


High impact information on vitamin H

  • According to a recently proposed theory for hindered diffusion through fibrous media, the diffusivity ratio is given by the product of a hydrodynamic factor (F) and a steric factor (S) [8].
  • It is now known that epibolin is identical to serum spreading factor, S protein, and vitronectin, and the current name for the protein is vitronectin [9].
  • Specular microscopy and computer-assisted morphometry was used to quantify central and peripheral endothelial cell density (ECD), coefficient of variation (COV) and the mean and standard deviation of the shape factor (S) over an 18-month period [10].
  • An efficient synthesis of a terminal alkyne derived from d-biotin was developed to provide an alternative for carboxyl-based biotinylation [11].
  • Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals [12].

Biological context of vitamin H


Anatomical context of vitamin H

  • Sleep-promoting factor (factor S) was extracted, partially purified, and concentrated from cerebrospinal fluid and from acid-acetone extracts of brain stem anc cortex of sleep-deprived goats and sheep [12].
  • By pull-down assays we demonstrate that SA covalently bound to the ribosome binds d-biotin [16].
  • Two new non-BoLA antigens were also detected, one completely included within the red blood cell factor S' (BoLy-S'), whereas a second (BoLy-w1) did not show any association with tested red blood cell factors [17].

Gene context of vitamin H

  • In contrast, transcripts for Growth/ Differentiation factor-S (GDF-5) were induced during a cellular condensation, and those for BMP-6 were induced during the formation of cartilage nodules, and declined as the differentiated ATDC5 cells became hypertrophic, and BMP-7 transcripts were only detected after cells became calcified [18].
  • Biotin sulfoxide reductase catalyzes the conversion of d-biotin d-sulfoxide (BSO) to d-biotin [19].
  • The JAS was scored in the traditional manner, yielding scores for ambitiousness (factor A), impatience (factor S), competitiveness (factor H) and job involvement (factor J) [20].
  • As determined by Sephadex G-50 chromatography, only an 8-fold molar excess of d-biotin relative to labelled streptavidin was required to displace 90% of label in the case of EB1, whereas even a 20-fold molar excess provided no detectable displacement of DB2 [21].
  • At 25 days of incubation, eggs from Large White turkey hens in two field trials were injected with 87 micrograms of exogenous d-biotin per egg [22].

Analytical, diagnostic and therapeutic context of vitamin H


  1. Vitronectin production by human yolk sac carcinoma cells resembling parietal endoderm. Cooper, S., Pera, M.F. Development (1988) [Pubmed]
  2. PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. Recio, E., Colinas, A., Rumbero, A., Aparicio, J.F., Martín, J.F. J. Biol. Chem. (2004) [Pubmed]
  3. In vitro biotinylation provides quantitative recovery of highly purified active lactose permease in a single step. Pouny, Y., Weitzman, C., Kaback, H.R. Biochemistry (1998) [Pubmed]
  4. Biotin sulfoxide reductase: Tryptophan 90 is required for efficient substrate utilization. Pollock, V.V., Conover, R.C., Johnson, M.K., Barber, M.J. Arch. Biochem. Biophys. (2003) [Pubmed]
  5. Determination of bioconcentration potential of tetrachloroethylene in marine algae by 13C. Wang, X., Harada, S., Watanabe, M., Koshikawa, H., Sato, K., Kimura, T. Chemosphere (1996) [Pubmed]
  6. Effects of sleep-promoting factor from human urine on sleep cycle of cats. García-Arrarás, J.E. Am. J. Physiol. (1981) [Pubmed]
  7. Muramyl peptide enhancement of slow-wave sleep. Krueger, J.M. Methods and findings in experimental and clinical pharmacology. (1986) [Pubmed]
  8. Hindered diffusion in agarose gels: test of effective medium model. Johnson, E.M., Berk, D.A., Jain, R.K., Deen, W.M. Biophys. J. (1996) [Pubmed]
  9. Vitronectin: effects on keratinocyte motility and inhibition of collagen-induced motility. Brown, C., Stenn, K.S., Falk, R.J., Woodley, D.T., O'Keefe, E.J. J. Invest. Dermatol. (1991) [Pubmed]
  10. Long-term changes in corneal endothelial morphology following wounding in the cat. Ling, T.L., Vannas, A., Holden, B.A. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  11. Synthesis of a biotin-derived alkyne for pd-catalyzed coupling reactions. Corona, C., Bryant, B.K., Arterburn, J.B. Org. Lett. (2006) [Pubmed]
  12. Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals. Pappenheimer, J.R., Koski, G., Fencl, V., Karnovsky, M.L., Krueger, J. J. Neurophysiol. (1975) [Pubmed]
  13. Biological activities of novel recombinant tumor necrosis factor having N-terminal amino acid sequences derived from cytotoxic factors produced by THP-1 cells. Soma, G., Tsuji, Y., Tanabe, Y., Noguchi, K., Kitahara-Tanabe, N., Gatanaga, T., Inagawa, H., Kawakami, M., Mizuno, D. Journal of biological response modifiers. (1988) [Pubmed]
  14. The coordinating properties of d-biotin. Sigel, H. Experientia (1981) [Pubmed]
  15. Carnitine profiles during differentiation and effects of carnitine on differentiation of 3T3-L1 cells. Cha, Y.S., Eun, J.S., Oh, S.H. Journal of medicinal food. (2003) [Pubmed]
  16. Soluble expression of aggregating proteins by covalent coupling to the ribosome. Sørensen, H.P., Kristensen, J.E., Sperling-Petersen, H.U., Mortensen, K.K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  17. Joint Report of the Fourth International Bovine Lymphocyte Antigen (BoLA) Workshop, East Lansing, Michigan, USA, 25 August 1990. Bernoco, D., Lewin, H.A., Andersson, L., Arriens, M.A., Byrns, G., Cwik, S., Davies, C.J., Hines, H.C., Leibold, W., Lie, O. Anim. Genet. (1991) [Pubmed]
  18. Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells. Akiyama, H., Shukunami, C., Nakamura, T., Hiraki, Y. Cell Struct. Funct. (2000) [Pubmed]
  19. Molecular cloning and expression of biotin sulfoxide reductase from Rhodobacter sphaeroides forma sp. denitrificans. Pollock, V.V., Barber, M.J. Arch. Biochem. Biophys. (1995) [Pubmed]
  20. Type A personalities tend to have low platelet monoamine oxidase activity. Smith, D.F. Acta psychiatrica Scandinavica. (1994) [Pubmed]
  21. Influence of endogenous biotin on the biodistribution of labelled biotin derivatives in mice. Rusckowski, M., Fogarasi, M., Virzi, F., Hnatowich, D.J. Nuclear medicine communications. (1995) [Pubmed]
  22. Increasing hatchability of turkey eggs with biotin egg injections. Robel, E.J., Christensen, V.L. Poult. Sci. (1987) [Pubmed]
  23. A comparison of the binding of biotin and biotinylated macromolecular ligands to an anti-biotin monoclonal antibody and to streptavidin. Vincent, P., Samuel, D. J. Immunol. Methods (1993) [Pubmed]
  24. Sleep-promoting material from human urine and its relation to factor S from brain. Krueger, J.M., Bacsik, J., García-Arrarás, J. Am. J. Physiol. (1980) [Pubmed]
WikiGenes - Universities