Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Caspase-9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. To explore the possibility that the genetic alterations of caspase-9 might be involved in the development of human cancers, we analyzed the entire coding region and all splice sites of the human caspase-9 gene for the detection of somatic mutations in a series of 353 cancers, including 180 gastric, 104 colorectal and 69 lung adenocarcinomas. Overall, we detected three somatic mutations of caspase-9, but all of the mutations were silent mutations. The mutations were observed in 2 of 104 colorectal carcinomas and 1 of 180 gastric carcinomas. These data indicate that the caspase-9 gene is rarely mutated in gastric, colorectal and lung adenocarcinomas, and suggest that caspase-9 gene mutation may not contribute to the pathogenesis of these cancers.[1]References
- Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas. Soung, Y.H., Lee, J.W., Kim, S.Y., Park, W.S., Nam, S.W., Lee, J.Y., Yoo, N.J., Lee, S.H. APMIS (2006) [Pubmed]
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