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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Carcinoma

 
 
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Disease relevance of Carcinoma

 

Psychiatry related information on Carcinoma

 

High impact information on Carcinoma

 

Chemical compound and disease context of Carcinoma

 

Biological context of Carcinoma

 

Anatomical context of Carcinoma

  • Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1 [11].
  • Seventeen of 27 patients with functioning islet-cell carcinomas had elevated plasma levels of hCG or one of its subunits (hCG-alpha and hCG-beta) [26].
  • The CAFs, which exhibit the traits of myofibroblasts, play a central role in promoting the growth of tumor cells through their ability to secrete stromal cell-derived factor 1 (SDF-1); CAFs promote angiogenesis by recruiting endothelial progenitor cells (EPCs) into carcinomas, an effect mediated in part by SDF-1 [11].
  • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes [27].
  • Immunohistochemical analyses of individual cells within tissue sections reveal differences in ras p21 expression in colon carcinomas compared with normal colonic epithelium, benign colon tumours and inflammatory or dysplastic colon lesions [28].
 

Gene context of Carcinoma

  • Aberrant transcripts of the FHIT locus were found in approximately 50% of esophageal, stomach, and colon carcinomas [29].
  • The Smad4/DPC4 tumour suppressor is inactivated in nearly half of pancreatic carcinomas and to a lesser extent in a variety of other cancers [30].
  • In this study, PIK3CA, encoding the p110alpha catalytic subunit of PI3K, is identified as an oncogene involved in upper aerodigestive tract (UADT) carcinomas [31].
  • BTG2 expression was found to be significantly reduced in a large proportion of human kidney and breast carcinomas, suggesting that BTG2 is a tumor suppressor that links p53 and Rb pathways in human tumorigenesis [32].
  • H-ras mutation is normally a hallmark of DMBA-TPA-induced skin tumors, but 70% of carcinomas from Pten+/- mice do not exhibit this mutation, and in all cases have lost the wild-type Pten allele [33].
  • In contrast to colon carcinomas, neither APC nor CTNNB1 point mutations seem to play a significant role in carcinogenesis, indicating divergent mechanisms of wnt/wingless control in the small and the large intestine [34].
 

Analytical, diagnostic and therapeutic context of Carcinoma

References

  1. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Kemp, C.J., Donehower, L.A., Bradley, A., Balmain, A. Cell (1993) [Pubmed]
  2. Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action. Ringold, G.M., Yamamoto, K.R., Tomkins, G.M., Bishop, M., Varmus, H.E. Cell (1975) [Pubmed]
  3. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Ropero, S., Fraga, M.F., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setien, F., Paz, M.F., Herranz, M., Palacios, J., Arango, D., Orntoft, T.F., Aaltonen, L.A., Schwartz, S., Esteller, M. Nat. Genet. (2006) [Pubmed]
  4. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cheng, A.M., Saxton, T.M., Sakai, R., Kulkarni, S., Mbamalu, G., Vogel, W., Tortorice, C.G., Cardiff, R.D., Cross, J.C., Muller, W.J., Pawson, T. Cell (1998) [Pubmed]
  5. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Hsu, I.C., Metcalf, R.A., Sun, T., Welsh, J.A., Wang, N.J., Harris, C.C. Nature (1991) [Pubmed]
  6. Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl)retinamide. Pollard, M., Luckert, P.H., Sporn, M.B. Cancer Res. (1991) [Pubmed]
  7. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Yuasa, Y., Nagasaki, H., Akiyama, Y., Sakai, H., Nakajima, T., Ohkura, Y., Takizawa, T., Koike, M., Tani, M., Iwai, T., Sugihara, K., Imai, K., Nakachi, K. Carcinogenesis (2005) [Pubmed]
  8. Prognostic significance of PCNA expression in laryngeal cancer. Saraç, S., Ayhan, A., Hosal, A.S., Kaya, S. Arch. Otolaryngol. Head Neck Surg. (1998) [Pubmed]
  9. HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. Fillies, T., Werkmeister, R., van Diest, P.J., Brandt, B., Joos, U., Buerger, H. BMC Cancer (2005) [Pubmed]
  10. The CD40 antigen and its ligand. Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Rousset, F., Saeland, S. Annu. Rev. Immunol. (1994) [Pubmed]
  11. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo, A., Gupta, P.B., Sgroi, D.C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V.J., Richardson, A.L., Weinberg, R.A. Cell (2005) [Pubmed]
  12. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Olive, K.P., Tuveson, D.A., Ruhe, Z.C., Yin, B., Willis, N.A., Bronson, R.T., Crowley, D., Jacks, T. Cell (2004) [Pubmed]
  13. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Eferl, R., Ricci, R., Kenner, L., Zenz, R., David, J.P., Rath, M., Wagner, E.F. Cell (2003) [Pubmed]
  14. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Kurose, K., Gilley, K., Matsumoto, S., Watson, P.H., Zhou, X.P., Eng, C. Nat. Genet. (2002) [Pubmed]
  15. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Schmidt, L., Duh, F.M., Chen, F., Kishida, T., Glenn, G., Choyke, P., Scherer, S.W., Zhuang, Z., Lubensky, I., Dean, M., Allikmets, R., Chidambaram, A., Bergerheim, U.R., Feltis, J.T., Casadevall, C., Zamarron, A., Bernues, M., Richard, S., Lips, C.J., Walther, M.M., Tsui, L.C., Geil, L., Orcutt, M.L., Stackhouse, T., Lipan, J., Slife, L., Brauch, H., Decker, J., Niehans, G., Hughson, M.D., Moch, H., Storkel, S., Lerman, M.I., Linehan, W.M., Zbar, B. Nat. Genet. (1997) [Pubmed]
  16. Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21. Finkel, T., Der, C.J., Cooper, G.M. Cell (1984) [Pubmed]
  17. Activation of ras oncogenes preceding the onset of neoplasia. Kumar, R., Sukumar, S., Barbacid, M. Science (1990) [Pubmed]
  18. Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Bernal, S.D., Lampidis, T.J., Summerhayes, I.C., Chen, L.B. Science (1982) [Pubmed]
  19. Gonadotropin-releasing hormone binding sites in human breast carcinoma. Eidne, K.A., Flanagan, C.A., Millar, R.P. Science (1985) [Pubmed]
  20. Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas. López-Ríos, F., Sánchez-Aragó, M., García-García, E., Ortega, A.D., Berrendero, J.R., Pozo-Rodríguez, F., López-Encuentra, A., Ballestín, C., Cuezva, J.M. Cancer Res. (2007) [Pubmed]
  21. Mutations of the VHL tumour suppressor gene in renal carcinoma. Gnarra, J.R., Tory, K., Weng, Y., Schmidt, L., Wei, M.H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F.M. Nat. Genet. (1994) [Pubmed]
  22. Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Bremner, R., Balmain, A. Cell (1990) [Pubmed]
  23. Mutations of the E-cadherin gene in human gynecologic cancers. Risinger, J.I., Berchuck, A., Kohler, M.F., Boyd, J. Nat. Genet. (1994) [Pubmed]
  24. Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Hodgson, G., Hager, J.H., Volik, S., Hariono, S., Wernick, M., Moore, D., Nowak, N., Albertson, D.G., Pinkel, D., Collins, C., Hanahan, D., Gray, J.W. Nat. Genet. (2001) [Pubmed]
  25. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Rudolph, K.L., Millard, M., Bosenberg, M.W., DePinho, R.A. Nat. Genet. (2001) [Pubmed]
  26. Ectopic production of chorionic gonadotropin and its subunits by islet-cell tumors. A specific marker for malignancy. Kahn, C.R., Rosen, S.W., Weintraub, B.D., Fajans, S.S., Gorden, P. N. Engl. J. Med. (1977) [Pubmed]
  27. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N., Perucho, M. Cell (1988) [Pubmed]
  28. Monoclonal antibodies define differential ras gene expression in malignant and benign colonic diseases. Thor, A., Horan Hand, P., Wunderlich, D., Caruso, A., Muraro, R., Schlom, J. Nature (1984) [Pubmed]
  29. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Ohta, M., Inoue, H., Cotticelli, M.G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P., Druck, T., Croce, C.M., Huebner, K. Cell (1996) [Pubmed]
  30. A structural basis for mutational inactivation of the tumour suppressor Smad4. Shi, Y., Hata, A., Lo, R.S., Massagué, J., Pavletich, N.P. Nature (1997) [Pubmed]
  31. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Singh, B., Reddy, P.G., Goberdhan, A., Walsh, C., Dao, S., Ngai, I., Chou, T.C., O-Charoenrat, P., Levine, A.J., Rao, P.H., Stoffel, A. Genes Dev. (2002) [Pubmed]
  32. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Boiko, A.D., Porteous, S., Razorenova, O.V., Krivokrysenko, V.I., Williams, B.R., Gudkov, A.V. Genes Dev. (2006) [Pubmed]
  33. Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Mao, J.H., To, M.D., Perez-Losada, J., Wu, D., Del Rosario, R., Balmain, A. Genes Dev. (2004) [Pubmed]
  34. Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis. Breuhahn, K., Singh, S., Schirmacher, P., Bläker, H. J. Pathol. (2008) [Pubmed]
  35. Endothelial-monocyte activating polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells. Schwarz, M.A., Kandel, J., Brett, J., Li, J., Hayward, J., Schwarz, R.E., Chappey, O., Wautier, J.L., Chabot, J., Lo Gerfo, P., Stern, D. J. Exp. Med. (1999) [Pubmed]
  36. Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma. Tannapfel, A., Wasner, M., Krause, K., Geissler, F., Katalinic, A., Hauss, J., Mössner, J., Engeland, K., Wittekind, C. J. Natl. Cancer Inst. (1999) [Pubmed]
  37. Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas. Holzmayer, T.A., Hilsenbeck, S., Von Hoff, D.D., Roninson, I.B. J. Natl. Cancer Inst. (1992) [Pubmed]
  38. Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. van der Flier, S., Brinkman, A., Look, M.P., Kok, E.M., Meijer-van Gelder, M.E., Klijn, J.G., Dorssers, L.C., Foekens, J.A. J. Natl. Cancer Inst. (2000) [Pubmed]
 
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