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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development.

The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.[1]

References

  1. Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Izpisúa-Belmonte, J.C., Tickle, C., Dollé, P., Wolpert, L., Duboule, D. Nature (1991) [Pubmed]
 
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