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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Antimalarial activity of a new family of analogues of manzamine A.

Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified analogues of manzamine A, which were designed to examine the roles of the A and D rings and of both the relative stereochemistry and the orientation of the beta-carboline heterocycle on the antimalarial activity of manzamine A, are described. [structure: see text][1]

References

  1. Antimalarial activity of a new family of analogues of manzamine A. Winkler, J.D., Londregan, A.T., Hamann, M.T. Org. Lett. (2006) [Pubmed]
 
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