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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Drug Therapy

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Disease relevance of Drug Therapy


Psychiatry related information on Drug Therapy


High impact information on Drug Therapy


Chemical compound and disease context of Drug Therapy


Biological context of Drug Therapy


Anatomical context of Drug Therapy


Associations of Drug Therapy with chemical compounds


Gene context of Drug Therapy

  • Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant phenotype because of overexpression of the multidrug transporter P-glycoprotein [34].
  • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy [35].
  • Thus, Bax mutation in mismatch repair--deficient tumors can cause resistance to death receptor--targeted therapy, but pre-exposure to chemotherapy rescues tumor sensitivity [36].
  • Therefore, up-regulation of utrophin by drug therapy is a plausible therapeutic approach in the treatment of DMD [37].
  • Because the yeast protein prenyltransferase could also prenylate human H-ras p21 precursor, the human DPR1-RAM1 analogue may be a useful target for anticancer chemotherapy [38].

Analytical, diagnostic and therapeutic context of Drug Therapy


  1. Advances in prostate cancer chemotherapy: a new era begins. Pienta, K.J., Smith, D.C. CA: a cancer journal for clinicians. (2005) [Pubmed]
  2. Treatment of primary breast cancer with chemotherapy and tamoxifen. Fisher, B., Redmond, C., Brown, A., Wolmark, N., Wittliff, J., Fisher, E.R., Plotkin, D., Bowman, D., Sachs, S., Wolter, J., Frelick, R., Desser, R., LiCalzi, N., Geggie, P., Campbell, T., Elias, E.G., Prager, D., Koontz, P., Volk, H., Dimitrov, N., Gardner, B., Lerner, H., Shibata, H. N. Engl. J. Med. (1981) [Pubmed]
  3. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. O'Connell, M.J., Martenson, J.A., Wieand, H.S., Krook, J.E., Macdonald, J.S., Haller, D.G., Mayer, R.J., Gunderson, L.L., Rich, T.A. N. Engl. J. Med. (1994) [Pubmed]
  4. A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. Freifeld, A., Marchigiani, D., Walsh, T., Chanock, S., Lewis, L., Hiemenz, J., Hiemenz, S., Hicks, J.E., Gill, V., Steinberg, S.M., Pizzo, P.A. N. Engl. J. Med. (1999) [Pubmed]
  5. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. Kelsen, D.P., Ginsberg, R., Pajak, T.F., Sheahan, D.G., Gunderson, L., Mortimer, J., Estes, N., Haller, D.G., Ajani, J., Kocha, W., Minsky, B.D., Roth, J.A. N. Engl. J. Med. (1998) [Pubmed]
  6. New treatments for smoking cessation. Hughes, J.R. CA: a cancer journal for clinicians. (2000) [Pubmed]
  7. Pharmacotherapy for nicotine dependence. Henningfield, J.E., Fant, R.V., Buchhalter, A.R., Stitzer, M.L. CA: a cancer journal for clinicians. (2005) [Pubmed]
  8. Buprenorphine suppresses cocaine self-administration by rhesus monkeys. Mello, N.K., Mendelson, J.H., Bree, M.P., Lukas, S.E. Science (1989) [Pubmed]
  9. A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia. Thase, M.E., Fava, M., Halbreich, U., Kocsis, J.H., Koran, L., Davidson, J., Rosenbaum, J., Harrison, W. Arch. Gen. Psychiatry (1996) [Pubmed]
  10. Pharmacotherapy plus psychotherapy for treatment of depression in active injection drug users. Stein, M.D., Solomon, D.A., Herman, D.S., Anthony, J.L., Ramsey, S.E., Anderson, B.J., Miller, I.W. Arch. Gen. Psychiatry (2004) [Pubmed]
  11. Highlights from recent National Surgical Adjuvant Breast and Bowel Project studies in the treatment and prevention of breast cancer. Fisher, B. CA: a cancer journal for clinicians. (1999) [Pubmed]
  12. Tumors of unknown origin. Greco, F.A., Hainsworth, J.D. CA: a cancer journal for clinicians. (1992) [Pubmed]
  13. Pituitary tumors: diagnosis and therapy. Cook, D.M. CA: a cancer journal for clinicians. (1983) [Pubmed]
  14. The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer. Levine, M.N., Gent, M., Hirsh, J., Arnold, A., Goodyear, M.D., Hryniuk, W., De Pauw, S. N. Engl. J. Med. (1988) [Pubmed]
  15. No increase in second tumors after cytotoxic chemotherapy for gestational trophoblastic tumors. Rustin, G.J., Rustin, F., Dent, J., Booth, M., Salt, S., Bagshawe, K.D. N. Engl. J. Med. (1983) [Pubmed]
  16. The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin. Smith, J.W., Longo, D.L., Alvord, W.G., Janik, J.E., Sharfman, W.H., Gause, B.L., Curti, B.D., Creekmore, S.P., Holmlund, J.T., Fenton, R.G. N. Engl. J. Med. (1993) [Pubmed]
  17. Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood. O'Driscoll, B.R., Hasleton, P.S., Taylor, P.M., Poulter, L.W., Gattameneni, H.R., Woodcock, A.A. N. Engl. J. Med. (1990) [Pubmed]
  18. Ondansetron compared with dexamethasone and metoclopramide as antiemetics in the chemotherapy of breast cancer with cyclophosphamide, methotrexate, and fluorouracil. Levitt, M., Warr, D., Yelle, L., Rayner, H.L., Lofters, W.S., Perrault, D.J., Wilson, K.S., Latreille, J., Potvin, M., Warner, E. N. Engl. J. Med. (1993) [Pubmed]
  19. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Azam, M., Latek, R.R., Daley, G.Q. Cell (2003) [Pubmed]
  20. Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? Zimm, S., Collins, J.M., Riccardi, R., O'Neill, D., Narang, P.K., Chabner, B., Poplack, D.G. N. Engl. J. Med. (1983) [Pubmed]
  21. Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Varley, H., Pickett, H.A., Foxon, J.L., Reddel, R.R., Royle, N.J. Nat. Genet. (2002) [Pubmed]
  22. Respiratory syncytial viral infection in children with compromised immune function. Hall, C.B., Powell, K.R., MacDonald, N.E., Gala, C.L., Menegus, M.E., Suffin, S.C., Cohen, H.J. N. Engl. J. Med. (1986) [Pubmed]
  23. Images in clinical medicine. Nail changes after chemotherapy. Slee, P.H. N. Engl. J. Med. (1997) [Pubmed]
  24. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. Bensinger, W.I., Martin, P.J., Storer, B., Clift, R., Forman, S.J., Negrin, R., Kashyap, A., Flowers, M.E., Lilleby, K., Chauncey, T.R., Storb, R., Appelbaum, F.R. N. Engl. J. Med. (2001) [Pubmed]
  25. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. Crawford, J., Ozer, H., Stoller, R., Johnson, D., Lyman, G., Tabbara, I., Kris, M., Grous, J., Picozzi, V., Rausch, G. N. Engl. J. Med. (1991) [Pubmed]
  26. The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis. Dutch Renal Artery Stenosis Intervention Cooperative Study Group. van Jaarsveld, B.C., Krijnen, P., Pieterman, H., Derkx, F.H., Deinum, J., Postma, C.T., Dees, A., Woittiez, A.J., Bartelink, A.K., Man in 't Veld, A.J., Schalekamp, M.A. N. Engl. J. Med. (2000) [Pubmed]
  27. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Johnson, J., Bagley, J., Skaznik-Wikiel, M., Lee, H.J., Adams, G.B., Niikura, Y., Tschudy, K.S., Tilly, J.C., Cortes, M.L., Forkert, R., Spitzer, T., Iacomini, J., Scadden, D.T., Tilly, J.L. Cell (2005) [Pubmed]
  28. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Molldrem, J.J., Lee, P.P., Wang, C., Felio, K., Kantarjian, H.M., Champlin, R.E., Davis, M.M. Nat. Med. (2000) [Pubmed]
  29. Neurofibrosarcoma at irradiation site in a patient with neurofibromatosis and Wilms' tumor. Chu, J.Y., O'Connor, D.M., Danis, R.K. CA: a cancer journal for clinicians. (1981) [Pubmed]
  30. Carcinoma of the anal canal. Ryan, D.P., Compton, C.C., Mayer, R.J. N. Engl. J. Med. (2000) [Pubmed]
  31. Chemotherapy with or without radiation therapy in limited small-cell carcinoma of the lung. Perry, M.C., Eaton, W.L., Propert, K.J., Ware, J.H., Zimmer, B., Chahinian, A.P., Skarin, A., Carey, R.W., Kreisman, H., Faulkner, C. N. Engl. J. Med. (1987) [Pubmed]
  32. Treatment of children and young adults with early-stage non-Hodgkin's lymphoma. Link, M.P., Shuster, J.J., Donaldson, S.S., Berard, C.W., Murphy, S.B. N. Engl. J. Med. (1997) [Pubmed]
  33. Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy. Markman, M., Sheidler, V., Ettinger, D.S., Quaskey, S.A., Mellits, E.D. N. Engl. J. Med. (1984) [Pubmed]
  34. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Bargou, R.C., Jürchott, K., Wagener, C., Bergmann, S., Metzner, S., Bommert, K., Mapara, M.Y., Winzer, K.J., Dietel, M., Dörken, B., Royer, H.D. Nat. Med. (1997) [Pubmed]
  35. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Muller, A.J., DuHadaway, J.B., Donover, P.S., Sutanto-Ward, E., Prendergast, G.C. Nat. Med. (2005) [Pubmed]
  36. Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. LeBlanc, H., Lawrence, D., Varfolomeev, E., Totpal, K., Morlan, J., Schow, P., Fong, S., Schwall, R., Sinicropi, D., Ashkenazi, A. Nat. Med. (2002) [Pubmed]
  37. Expression of full-length utrophin prevents muscular dystrophy in mdx mice. Tinsley, J., Deconinck, N., Fisher, R., Kahn, D., Phelps, S., Gillis, J.M., Davies, K. Nat. Med. (1998) [Pubmed]
  38. Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. Schafer, W.R., Trueblood, C.E., Yang, C.C., Mayer, M.P., Rosenberg, S., Poulter, C.D., Kim, S.H., Rine, J. Science (1990) [Pubmed]
  39. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. Overgaard, M., Hansen, P.S., Overgaard, J., Rose, C., Andersson, M., Bach, F., Kjaer, M., Gadeberg, C.C., Mouridsen, H.T., Jensen, M.B., Zedeler, K. N. Engl. J. Med. (1997) [Pubmed]
  40. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. Matthay, K.K., Villablanca, J.G., Seeger, R.C., Stram, D.O., Harris, R.E., Ramsay, N.K., Swift, P., Shimada, H., Black, C.T., Brodeur, G.M., Gerbing, R.B., Reynolds, C.P. N. Engl. J. Med. (1999) [Pubmed]
  41. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group. Hortobagyi, G.N., Theriault, R.L., Porter, L., Blayney, D., Lipton, A., Sinoff, C., Wheeler, H., Simeone, J.F., Seaman, J., Knight, R.D. N. Engl. J. Med. (1996) [Pubmed]
  42. Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. Herman, T.S., Einhorn, L.H., Jones, S.E., Nagy, C., Chester, A.B., Dean, J.C., Furnas, B., Williams, S.D., Leigh, S.A., Dorr, R.T., Moon, T.E. N. Engl. J. Med. (1979) [Pubmed]
  43. Human granulocyte colony-stimulating factor after induction chemotherapy in children with acute lymphoblastic leukemia. Pui, C.H., Boyett, J.M., Hughes, W.T., Rivera, G.K., Hancock, M.L., Sandlund, J.T., Synold, T., Relling, M.V., Ribeiro, R.C., Crist, W.M., Evans, W.E. N. Engl. J. Med. (1997) [Pubmed]
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