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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Drug Therapy

 
 
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Disease relevance of Drug Therapy

 

Psychiatry related information on Drug Therapy

 

High impact information on Drug Therapy

 

Chemical compound and disease context of Drug Therapy

 

Biological context of Drug Therapy

 

Anatomical context of Drug Therapy

 

Associations of Drug Therapy with chemical compounds

 

Gene context of Drug Therapy

  • Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant phenotype because of overexpression of the multidrug transporter P-glycoprotein [34].
  • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy [35].
  • Thus, Bax mutation in mismatch repair--deficient tumors can cause resistance to death receptor--targeted therapy, but pre-exposure to chemotherapy rescues tumor sensitivity [36].
  • Therefore, up-regulation of utrophin by drug therapy is a plausible therapeutic approach in the treatment of DMD [37].
  • Because the yeast protein prenyltransferase could also prenylate human H-ras p21 precursor, the human DPR1-RAM1 analogue may be a useful target for anticancer chemotherapy [38].
 

Analytical, diagnostic and therapeutic context of Drug Therapy

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