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Raffa, R.B. et al.

Raffa, Baron, Tallarida,

Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.

Previous investigators have provided radioimmunological and immunocytochemical evidence for an enkephalinergic (opioid) system in Planaria and described naloxone-sensitive qualitative behavioral responses to kappa-opioid receptor agonists. We report the application of Schild-analysis to the antagonism of a selective kappa agonist (U-50,488H) by a selective kappa antagonist (nor-BNI) in a quantitative in vivo endpoint. The results provide further evidence of a kappa-opioid-like receptor in planarians.[1]

References

Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria. Raffa, R.B., Baron, D.A., Tallarida, R.J. Eur. J. Pharmacol. (2006) [Pubmed]

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