The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Planarians


High impact information on Planarians

  • Here we report the identification and characterization of nou-darake (ndk), a gene encoding a fibroblast growth factor receptor (FGFR)-like molecule specifically expressed in the head region of the planarian Dugesia japonica [3].
  • Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians [4].
  • To identify potential pattern-control genes in planarian regeneration, we have isolated two homeobox-containing genes, Dth-1 and Dth-2 [Dugesia (Girardia) tigrina homeobox], by using degenerate oligonucleotides corresponding to the most conserved amino acid sequence from helix-3 of the homeodomain [5].
  • In this study, we identified a homologue of the Drosophila PUF gene Pumilio (DjPum) in the planarian Dugesia japonica, with an expression pattern preferentially restricted to neoblasts [6].
  • Inactivation of both Pax6A and Pax6B by RNA-mediated gene interference (RNAi) inhibits neither eye regeneration nor eye maintenance, suggesting that the genetic network that controls this process is not triggered by Pax6 in planarians [7].

Chemical compound and disease context of Planarians


Biological context of Planarians


Anatomical context of Planarians


Associations of Planarians with chemical compounds


Gene context of Planarians

  • FGFR-related gene nou-darake restricts brain tissues to the head region of planarians [3].
  • Somatostatin-like peptide and regeneration capacities in planarians [19].
  • The involvement of Pax6 and six1 and six3 genes, which encode highly conserved transcription factors, in the genetic control of eye development in organisms ranging from planarians to humans argues strongly for a monophyletic origin of the eye [20].
  • The presence of a neuropeptide immunologically related to somatostatin (SRIF) has been investigated in the neurosecretory cells of two regenerating planarian species (Dugesia lugubris and Dendrocoelum lacteum) [19].
  • An MCM2-related gene is expressed in proliferating cells of intact and regenerating planarians [21].

Analytical, diagnostic and therapeutic context of Planarians


  1. Toxicity of selenium (Na2SeO3) and mercury (HgCl2) on the planarian Dugesia gonocephala. Congiu, A.M., Casu, S., Ugazio, G. Res. Commun. Chem. Pathol. Pharmacol. (1989) [Pubmed]
  2. Cocarcinogenesis between cadmium and Aroclor 1254 in planarians is enhanced by inhibition of glutathione synthesis. Schaeffer, D.J., Tehseen, W.M., Johnson, L.R., McLaughlin, G.L., Hassan, A.S., Reynolds, H.A., Hansen, L.G. Quality assurance (San Diego, Calif.) (1991) [Pubmed]
  3. FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Cebrià, F., Kobayashi, C., Umesono, Y., Nakazawa, M., Mineta, K., Ikeo, K., Gojobori, T., Itoh, M., Taira, M., Sánchez Alvarado, A., Agata, K. Nature (2002) [Pubmed]
  4. Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians. Pineda, D., Gonzalez, J., Callaerts, P., Ikeo, K., Gehring, W.J., Salo, E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Planarian homeobox genes: cloning, sequence analysis, and expression. Garcia-Fernàndez, J., Baguñà, J., Saló, E. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. DjPum, a homologue of Drosophila Pumilio, is essential to planarian stem cell maintenance. Salvetti, A., Rossi, L., Lena, A., Batistoni, R., Deri, P., Rainaldi, G., Locci, M.T., Evangelista, M., Gremigni, V. Development (2005) [Pubmed]
  7. The genetic network of prototypic planarian eye regeneration is Pax6 independent. Pineda, D., Rossi, L., Batistoni, R., Salvetti, A., Marsal, M., Gremigni, V., Falleni, A., Gonzalez-Linares, J., Deri, P., Saló, E. Development (2002) [Pubmed]
  8. Neurobehavioral toxicity of cadmium sulfate to the planarian Dugesia dorotocephala. Grebe, E., Schaeffer, D.J. Bulletin of environmental contamination and toxicology. (1991) [Pubmed]
  9. Comparative acute toxicity of DDT metabolites among American and European species of planarians. Bonner, J.C., Wells, M.R. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1987) [Pubmed]
  10. Djeyes absent (Djeya) controls prototypic planarian eye regeneration by cooperating with the transcription factor Djsix-1. Mannini, L., Rossi, L., Deri, P., Gremigni, V., Salvetti, A., Saló, E., Batistoni, R. Dev. Biol. (2004) [Pubmed]
  11. Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Newmark, P.A., Sánchez Alvarado, A. Dev. Biol. (2000) [Pubmed]
  12. POU-domain sequences from the flatworm Dugesia tigrina. Stuart, G.W., Zhu, Z., Sampath, K., King, M.W. Gene (1995) [Pubmed]
  13. Circadian rhythm of serotonin levels in planarians. Itoh, M.T., Igarashi, J. Neuroreport (2000) [Pubmed]
  14. Planarian mitochondria. I. Heterogeneity of cytochrome c oxidase subunit I gene sequences in the freshwater planarian, Dugesia japonica. Bessho, Y., Ohama, T., Osawa, S. J. Mol. Evol. (1992) [Pubmed]
  15. kappa-Opioid withdrawal in Planaria. Raffa, R.B., Stagliano, G.W., Umeda, S. Neurosci. Lett. (2003) [Pubmed]
  16. Circadian rhythms of melatonin-synthesizing enzyme activities and melatonin levels in planarians. Itoh, M.T., Shinozawa, T., Sumi, Y. Brain Res. (1999) [Pubmed]
  17. Reinforcing effects of methamphetamine in planarians. Kusayama, T., Watanabe, S. Neuroreport (2000) [Pubmed]
  18. Cocaine and kappa-opioid withdrawal in Planaria blocked by D-, but not L-, glucose. Umeda, S., Stagliano, G.W., Raffa, R.B. Brain Res. (2004) [Pubmed]
  19. Somatostatin-like peptide and regeneration capacities in planarians. Bautz, A., Schilt, J. Gen. Comp. Endocrinol. (1986) [Pubmed]
  20. New perspectives on eye development and the evolution of eyes and photoreceptors. Gehring, W.J. J. Hered. (2005) [Pubmed]
  21. An MCM2-related gene is expressed in proliferating cells of intact and regenerating planarians. Salvetti, A., Rossi, L., Deri, P., Batistoni, R. Dev. Dyn. (2000) [Pubmed]
  22. Molecular identification of a G protein-coupled receptor family which is expressed in planarians. Saitoh, O., Yuruzume, E., Watanabe, K., Nakata, H. Gene (1997) [Pubmed]
  23. Effects of dopaminergic agents on monoamine levels and motor behaviour in planaria. Algeri, S., Carolei, A., Ferretti, P., Gallone, C., Palladini, G., Venturini, G. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1983) [Pubmed]
  24. A reverse-phase HPLC and fluorescence detection method for measurement of 5-hydroxytryptamine (serotonin) in Planaria. Umeda, S., Stagliano, G.W., Borenstein, M.R., Raffa, R.B. Journal of pharmacological and toxicological methods. (2005) [Pubmed]
WikiGenes - Universities