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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lack of efficacy of d-propranolol in neuroleptic-induced akathisia.

d-Propranolol lacks clinically significant beta-adrenergic receptor blocking properties, but has the same membrane stabilizing effects as racemic (d,l) propranolol. To assess the role of beta-blockade versus membrane stabilization or other shared nonspecific effects in the therapeutic action of propranolol in neuroleptic-induced akathisia (NIA) we treated 11 patients with NIA in a crossover, double-blind study of d-propranolol versus placebo. Akathisia scores were unchanged after both d-propranolol and placebo. Eight patients were subsequently treated in a nonblind manner with racemic propranolol, with a significant reduction in akathisia scores. These findings suggest that beta-blockade, not membrane stabilization or other shared nonspecific effects, contributes to the efficacy of propranolol in NIA.[1]


  1. Lack of efficacy of d-propranolol in neuroleptic-induced akathisia. Adler, L.A., Angrist, B., Fritz, P., Rotrosen, J., Mallya, G., Lipinski, J.F. Neuropsychopharmacology (1991) [Pubmed]
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