Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Pedersen, S.S. et al.

Susanne S. Pedersen, Johan Denollet, Andrew T. L. Ong, Patrick W. Serruys, Ruud A. M. Erdman, Ron T. van Domburg,

Impaired health status in Type D patients following PCI in the drug-eluting stent era.

BACKGROUND: Drug-eluting stenting reduces restenosis post-percutaneous coronary intervention (PCI), but subgroups of patients may not benefit optimally from this procedure. We examined the impact of Type D personality on health status over time and the clinical relevance of Type D as a predictor of impaired health status at 12 months in unselected post-PCI patients. METHODS: Consecutive patients (n=692) participating in the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed the Type D Scale at 6 months and the Short Form Health Survey 36 (SF-36) at 6 and 12 months post-PCI. RESULTS: Although there was a significant improvement in health status over time (p<0.001), Type D patients reported a substantially lower score on all health status domains of the SF-36 compared with non-Type D patients (p<0.001). Type D personality was an independent predictor of impaired health status on all SF-36 sub domains at 12 months except for physical functioning, adjusting for baseline demographic and clinical variables and health status at 6 months. In these adjusted analyses, Type D personality increased the likelihood of impaired health status at 12 months post-PCI from 60% (OR: 1.60; 95% CI: 1.04-2.46) to almost 300% (OR: 3.99; 95% CI: 2.52-6.32), varying among the parameters analyzed. CONCLUSIONS: Type D personality was associated with impaired health status in post-PCI patients treated in the drug-eluting stent era. The role of personality factors as determinants of clinical outcome and health status should not be overlooked as these factors may have much explanatory power.[1]

References

Impaired health status in Type D patients following PCI in the drug-eluting stent era. Pedersen, S.S., Denollet, J., Ong, A.T., Serruys, P.W., Erdman, R.A., van Domburg, R.T. Int. J. Cardiol. (2007) [Pubmed]

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