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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis.

A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 microM and also showed antibacterial activity against Escherichia coli and S. aureus.[1]

References

  1. Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis. Yoo, J.S., Zheng, C.J., Lee, S., Kwak, J.H., Kim, W.G. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
 
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