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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.

Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA.[1]

References

  1. BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. Guo, Z., Tang, W., Yuan, J., Chen, X., Wan, B., Gu, X., Luo, K., Wang, Y., Yu, L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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