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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.

We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.[1]

References

  1. Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae. Szabó, D., Silveira, F., Hujer, A.M., Bonomo, R.A., Hujer, K.M., Marsh, J.W., Bethel, C.R., Doi, Y., Deeley, K., Paterson, D.L. Antimicrob. Agents Chemother. (2006) [Pubmed]
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