Membrane binding and subcellular targeting of C2 domains.
C2 domains are a ubiquitous structural module and many of them function in Ca(2+)-dependent membrane binding and thereby serve as Ca(2+) effectors for divergent Ca(2+)-mediated cellular processes. Extensive structural, biochemical, biophysical, and cellular studies of C2 domains and host proteins in the past decade have shown that due to their structural diversity C2 domains have disparate Ca(2+) sensitivity, lipid selectivity and membrane binding mechanisms. This review summarizes the basic structural and functional properties of C2 domains as well as recent findings on Ca(2+) and membrane binding, lipid selectivity, and subcellular localization of C2 domains and their host proteins.[1]References
- Membrane binding and subcellular targeting of C2 domains. Cho, W., Stahelin, R.V. Biochim. Biophys. Acta (2006) [Pubmed]
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