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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Efficient microwave-assisted tandem N- to s-acyl transfer and thioester exchange for the preparation of a glycosylated Peptide thioester.

A peptide carrying a mercaptomethylated proline derivative at the C-terminus was prepared by solid-phase peptide synthesis (SPPS) and converted to the thioester of 3-mercaptopropionic acid (MPA) by aqueous MPA under microwave irradiation conditions. This post-SPPS thioesterification reaction was successfully applied to the synthesis of a glycopeptide thioester composed of 25 amino acid (AA) residues, which was then used for the preparation of a 61-AA glycopeptide by the thioester condensation method.[1]

References

  1. Efficient microwave-assisted tandem N- to s-acyl transfer and thioester exchange for the preparation of a glycosylated Peptide thioester. Nagaike, F., Onuma, Y., Kanazawa, C., Hojo, H., Ueki, A., Nakahara, Y., Nakahara, Y. Org. Lett. (2006) [Pubmed]
 
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