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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CSF neurofilament levels: a potential prognostic marker in Guillain-Barr?? syndrome.

Long-term morbidity from Guillain-Barr?? syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (>0.73 ng/mL) predicted worse motor and functional outcome.[1]

References

  1. CSF neurofilament levels: a potential prognostic marker in Guillain-Barr?? syndrome. Petzold, A., Hinds, N., Murray, N.M., Hirsch, N.P., Grant, D., Keir, G., Thompson, E.J., Reilly, M.M. Neurology (2006) [Pubmed]
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