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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Identification of pentadecapeptide mimicking muramyl peptide.

We used monoclonal antibody, generated against N-acetylglucosaminyl-beta1-4-N-acetylmuramyl-alanyl-d-isoglutamine ( GMDP), and phage display libraries of random peptides to select for oligopeptides, that mimic GMDP in their biological activity. Selected phage clones displayed a peptide RVPPRYHAKISPMVN (called RN-peptide) on their surface. This peptide was synthesized. RN-peptide was shown to augment the antibody response to ovalbumin in mice while the peptide was non-immunogenic and non-pyrogenic. We also characterized adjuvant activity of 14-, 10- and 7-mer analogs of RN-peptide truncated at the C-terminus and found them to be active. Because both carbohydrate and peptide fragments are critical for the biological activity of muramyl peptides, the results indicate that RN-peptide mimicks the spatial structure of intact GMDP.[1]


  1. Identification of pentadecapeptide mimicking muramyl peptide. Laman, A.G., Shepelyakovskaya, A.O., Berezin, I.A., Boziev, K.M., Rodionov, I.L., Chulina, I.A., Malakhova, G.V., Brovko, F.A., Murashev, A.N., Korpela, T.K., Nesmeyanov, V.A. Vaccine (2007) [Pubmed]
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