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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bipolar disorder evolved as an adaptation to severe climate.

Keller & Miller (K&M) assert that mental disorders could not have evolved as adaptations, but they fail to make their case against the theory of the evolutionary origin of bipolar disorder that I have proposed (Sherman 2001). Such an idea may be unorthodox, but it has considerable explanatory power and heuristic value.[1]


  1. Bipolar disorder evolved as an adaptation to severe climate. Sherman, J.A. The Behavioral and brain sciences (2006) [Pubmed]
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