The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Serylan     1-(1- phenylcyclohexyl)piperidine

Synonyms: Cadillac, Cyclones, Stardust, Sernyl, Dust, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Sernyl

 

Psychiatry related information on Sernyl

 

High impact information on Sernyl

  • SUMMARY: Crystal structures of the insulin receptor substrate-1 (IRS-1) phosphotyrosine-binding (PTB) domain, alone and complexed with the juxtamembrane region of the insulin receptor, show how this domain recognizes phosphorylated "NPXY" sequence motifs [10].
  • Superweed study falters as seed firms deny access to transgene [11].
  • Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts [12].
  • Initially discovered in the landmark genetic screen for Drosophila developmental mutants, bazooka, crumbs, shotgun and stardust mutants exhibit severe disruption in apicobasal polarity in embryonic epithelia, resulting in multilayered epithelia, tissue disintegration, and defects in cuticle formation [12].
  • Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity [13].
 

Chemical compound and disease context of Sernyl

 

Biological context of Sernyl

 

Anatomical context of Sernyl

 

Associations of Sernyl with other chemical compounds

 

Gene context of Sernyl

  • This 38-bp deletion caused a 90% reduction in the CYC1 transcripts, which were heterogeneous in size, aberrantly long, and presumably labile (K. S. Zaret and F. Sherman, Cell 28:563-573, 1982) [30].
  • NIP7 encodes a conserved Saccharomyces cerevisiae nucleolar protein that is required for 60S subunit biogenesis (N. I. T. Zanchin, P. Roberts, A. DeSilva, F. Sherman, and D. S. Goldfarb, Mol. Cell. Biol. 17:5001-5015, 1997) [31].
  • We have also characterized, in more detail, the amino terminus of Drosophila Stardust and demonstrate that the interaction mechanism between Stardust and Drosophila Par6 is evolutionarily conserved [32].
  • Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain [33].
  • Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila [34].
 

Analytical, diagnostic and therapeutic context of Sernyl

  • Phencyclidine ("PCP" or "angel dust") and some of its derivatives are psychotomimetic drugs that have been used in general anesthesia for some time [35].
  • After photolabeling of the membrane-bound receptor under equilibrium conditions in the presence of agonist and with or without phencyclidine (a specific ligand for the high-affinity site for noncompetitive blockers), the purified labeled gamma subunit was digested with trypsin, and the resulting fragments were fractionated by HPLC [36].
  • Sequence analysis of peptide mixtures containing various amounts of highly hydrophobic fragments showed that three amino acids are labeled by [3H]chlorpromazine in a phencyclidine-sensitive manner: Thr-253, Ser-257, and Leu-260 [36].
  • There is a good correlation between the apparent affinities of a series of phencyclidine analogs for the phencyclidine receptor and the pharacological activities of these analogs as measured by the rotarod assay [37].
  • Rats learned to lever-press when such behavior was reinforced by microinjections of phencyclidine (PCP) directly into the ventromedial (shell) region of nucleus accumbens, indicating that the drug has direct rewarding actions in that region [38].

References

  1. Phencyclidine, lysergic acid diethylamide, and mescaline: cerebral artery spasms and hallucinogenic activity. Altura, B.T., Altura, B.M. Science (1981) [Pubmed]
  2. Phencyclidine. Nine cases of poisoning. Liden, C.B., Lovejoy, F.H., Costello, C.E. JAMA (1975) [Pubmed]
  3. Intracranial hemorrhage associated with phencyclidine abuse. Bessen, H.A. JAMA (1982) [Pubmed]
  4. Phencyclidine abuse mimicking head injury. Corales, R.L., Maull, K.I., Becker, D.P. JAMA (1980) [Pubmed]
  5. Phencyclidine-associated acute rhabdomyolysis. Cogen, F.C., Rigg, G., Simmons, J.L., Domino, E.F. Ann. Intern. Med. (1978) [Pubmed]
  6. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Fu, Y.H., Kuhl, D.P., Pizzuti, A., Pieretti, M., Sutcliffe, J.S., Richards, S., Verkerk, A.J., Holden, J.J., Fenwick, R.G., Warren, S.T. Cell (1991) [Pubmed]
  7. Phencyclidine poisoning. Tong, T.G., Benowitz, N.L., Becker, C.E., Forni, P.J., Boerner, U. JAMA (1975) [Pubmed]
  8. Bipolar disorder evolved as an adaptation to severe climate. Sherman, J.A. The Behavioral and brain sciences (2006) [Pubmed]
  9. The paradox of phencyclidine (PCP) abuse. Stillman, R., Petersen, R.C. Ann. Intern. Med. (1979) [Pubmed]
  10. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Eck, M.J., Dhe-Paganon, S., Trüb, T., Nolte, R.T., Shoelson, S.E. Cell (1996) [Pubmed]
  11. Superweed study falters as seed firms deny access to transgene. Dalton, R., Diego, S. Nature (2002) [Pubmed]
  12. Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Hong, Y., Stronach, B., Perrimon, N., Jan, L.Y., Jan, Y.N. Nature (2001) [Pubmed]
  13. Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Bachmann, A., Schneider, M., Theilenberg, E., Grawe, F., Knust, E. Nature (2001) [Pubmed]
  14. MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Sharp, F.R., Jasper, P., Hall, J., Noble, L., Sagar, S.M. Ann. Neurol. (1991) [Pubmed]
  15. Isomaltulose synthase (PalI) of Klebsiella sp. LX3. Crystal structure and implication of mechanism. Zhang, D., Li, N., Lok, S.M., Zhang, L.H., Swaminathan, K. J. Biol. Chem. (2003) [Pubmed]
  16. Two Crystal Structures of the Isochorismate Pyruvate Lyase from Pseudomonas aeruginosa. Zaitseva, J., Lu, J., Olechoski, K.L., Lamb, A.L. J. Biol. Chem. (2006) [Pubmed]
  17. Mechanism of catalysis of the cofactor-independent phosphoglycerate mutase from Bacillus stearothermophilus. Crystal structure of the complex with 2-phosphoglycerate. Jedrzejas, M.J., Chander, M., Setlow, P., Krishnasamy, G. J. Biol. Chem. (2000) [Pubmed]
  18. Intermolecular Transfer of Copper Ions from the CopC Protein of Pseudomonas syringae. Crystal Structures of Fully Loaded Cu(I)Cu(II) Forms. Zhang, L., Koay, M., Maher, M.J., Xiao, Z., Wedd, A.G. J. Am. Chem. Soc. (2006) [Pubmed]
  19. Localisation of phencyclidine-induced changes in brain energy metabolism. Meibach, R.C., Glicks, D., Cox, R., Maayani, S. Nature (1979) [Pubmed]
  20. Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Jentsch, J.D., Redmond, D.E., Elsworth, J.D., Taylor, J.R., Youngren, K.D., Roth, R.H. Science (1997) [Pubmed]
  21. Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential. Johnson, K.M., Jones, S.M. Annu. Rev. Pharmacol. Toxicol. (1990) [Pubmed]
  22. Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig. Roman, F., Pascaud, X., Chomette, G., Bueno, L., Junien, J.L. Gastroenterology (1989) [Pubmed]
  23. Addictive drugs and brain stimulation reward. Wise, R.A. Annu. Rev. Neurosci. (1996) [Pubmed]
  24. Biliary secretory immunoglobulin A is a major constituent of the new group of cholesterol crystal-binding proteins. Busch, N., Lammert, F., Matern, S. Gastroenterology (1998) [Pubmed]
  25. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Moghaddam, B., Adams, B.W. Science (1998) [Pubmed]
  26. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Brady, K.T., Balster, R.L., May, E.L. Science (1982) [Pubmed]
  27. Glutamatergic mechanisms in schizophrenia. Tsai, G., Coyle, J.T. Annu. Rev. Pharmacol. Toxicol. (2002) [Pubmed]
  28. Noncompetitive excitatory amino acid receptor antagonists. Lodge, D., Johnson, K.M. Trends Pharmacol. Sci. (1990) [Pubmed]
  29. The Crystal Structure of Arabidopsis thaliana Allene Oxide Cyclase: Insights into the Oxylipin Cyclization Reaction. Hofmann, E., Zerbe, P., Schaller, F. Plant Cell (2006) [Pubmed]
  30. Signals that produce 3' termini in CYC1 mRNA of the yeast Saccharomyces cerevisiae. Russo, P., Li, W.Z., Guo, Z., Sherman, F. Mol. Cell. Biol. (1993) [Pubmed]
  31. Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Zanchin, N.I., Goldfarb, D.S. Mol. Cell. Biol. (1999) [Pubmed]
  32. Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust. Wang, Q., Hurd, T.W., Margolis, B. J. Biol. Chem. (2004) [Pubmed]
  33. Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. Shimizu, T., Seto, A., Maita, N., Hamada, K., Tsukita, S., Tsukita, S., Hakoshima, T. J. Biol. Chem. (2002) [Pubmed]
  34. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97. Bachmann, A., Timmer, M., Sierralta, J., Pietrini, G., Gundelfinger, E.D., Knust, E., Thomas, U. J. Cell. Sci. (2004) [Pubmed]
  35. Phencyclidine-induced immunodepression. Khansari, N., Whitten, H.D., Fudenberg, H.H. Science (1984) [Pubmed]
  36. The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel. Revah, F., Galzi, J.L., Giraudat, J., Haumont, P.Y., Lederer, F., Changeux, J.P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  37. Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. Vincent, J.P., Kartalovski, B., Geneste, P., Kamenka, J.M., Lazdunski, M. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  38. Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. Carlezon, W.A., Wise, R.A. J. Neurosci. (1996) [Pubmed]
 
WikiGenes - Universities