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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

SNPs analysis by use of oligonucleotides containing 2'-O-methyl-2-thiouridines.

In this study, we report an improved method for the synthesis of oligonucleotides containing 2-thiouridine (s2U) derivatives. The hybridization affinity and base pair recognition ability of oligonucleotides having 2-thiouracil moieties with both the complementary RNAs and DNAs were also studied in detail. These results indicate that oligonucleotides containing s2U derivatives could be used as powerful tools for chip-based SNPs detection.[1]

References

  1. SNPs analysis by use of oligonucleotides containing 2'-O-methyl-2-thiouridines. Okamoto, I., Seio, K., Sekine, M. Nucleic acids symposium series (2004) (2005) [Pubmed]
 
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