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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effect of benzylic oxygen on the cytotoxic activity for colon 26 cell line of phenolic lignans.

The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9'-epoxylignan and oxidized 9,9'-epoxylignan were examined. (-)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC(50)=9 mug/ml) of the lactone-type lignans. 7,7'-Oxomatairesinol having same steric configuration as that of (-)-matairesinol showed greater activity (LC(50)=25 mug/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9'-epoxylignan and 7,7'-oxo-9,9'-epoxylignan having same steric configurations as (-)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.[1]

References

  1. Effect of benzylic oxygen on the cytotoxic activity for colon 26 cell line of phenolic lignans. Yamauchi, S., Sugahara, T., Nakashima, Y., Abe, K., Hayashi, Y., Akiyama, K., Kishida, T., Maruyama, M. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
 
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