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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chaotic license for genetic instability and cancer.

Replication initiation factors are essential for cell proliferation and thus are not expected to be disrupted in cancers. Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas.[1]

References

  1. Chaotic license for genetic instability and cancer. Dutta, A. Nat. Genet. (2007) [Pubmed]
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