Fanconi anemia and breast cancer susceptibility.
Two new studies show that the Fanconi anemia complementation group N results from biallelic mutations in PALB2, which encodes a recently identified interaction partner of the breast cancer susceptibility protein BRCA2. A third study shows that monoallelic PALB2 mutations are associated with breast cancer susceptibility, providing yet more links between Fanconi anemia, homologous recombination repair and cancer predisposition.[1]References
- Fanconi anemia and breast cancer susceptibility. Patel, K.J. Nat. Genet. (2007) [Pubmed]
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