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Sanz, M.A. et al.

M.A. Sanz, M. Labopin, N.C. Gorin, J. de la Rubia, W. Arcese, G. Meloni, A. Bacigalupo, P. Alessandrino, E. Carreras, A. Iriondo, N. Novitzky, P. Jacobs, G. Bandini, F. Lo-Coco, F. Frassoni, V. Rocha,

Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: a survey of the European Cooperative Group for Blood and Marrow Transplantation.

We performed a survey of the European Cooperative Group for Blood and Marrow Transplantation to analyze the outcome of 625 acute promyelocytic leukemia (APL) patients transplanted with auto- or allogeneic-hematopoietic stem cell transplantation (autoHSCT, alloHSCT) after 1993, in first (CR1) or in second complete remission (CR2). Leukemia-free survival (LFS) at 5 years in CR1 was 69% for 149 patients autografted and 68% for 144 patients allografted, whereas in CR2, LFS was 51% in 195 autoHSCT and 59% in 137 alloHSCT recipients, respectively. In the group of autoHSCT for CR1 (n=149), higher relapse incidence (RI) was associated with shorter time from diagnosis to transplant (<7.6 months); transplant-related mortality (TRM) was increased in older patients (>47 years), whereas for CR2, longer time from diagnosis to transplant (>18 months) was associated with increased LFS and decreased RI. In the alloHSCT group for CR1 (n=144), age (<33 years) was associated with increased LFS and decreased TRM and for CR2 (n=137), the use of mobilized peripheral blood stem cells was associated with decreased TRM. Female recipient, a female donor to male recipient and transplants performed before 1997 were associated with decreased RI. In conclusion, HSCT still appears to have a role in APL, especially for patients in CR2.[1]

References

Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: a survey of the European Cooperative Group for Blood and Marrow Transplantation. Sanz, M.A., Labopin, M., Gorin, N.C., de la Rubia, J., Arcese, W., Meloni, G., Bacigalupo, A., Alessandrino, P., Carreras, E., Iriondo, A., Novitzky, N., Jacobs, P., Bandini, G., Lo-Coco, F., Frassoni, F., Rocha, V. Bone Marrow Transplant. (2007) [Pubmed]

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