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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Stem Cells

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Disease relevance of Stem Cells


Psychiatry related information on Stem Cells


High impact information on Stem Cells


Chemical compound and disease context of Stem Cells


Biological context of Stem Cells

  • The PML-RAR alpha fusion protein of APL renders haemopoietic progenitor cells resistant to Fas-, TNF- and IFN-induced apoptosis with a lack of caspase 3 activation, thus acting as a Pml dominant-negative product [20].
  • We studied the effect of lithium on murine hematopoiesis in a liquid culture system providing for the prolonged growth of stem cells and their progeny [21].
  • Transcription of the HO gene is controlled by at least eleven trans-acting regulators, which are responsible for limiting expression to mother cells and to one period in the cell cycle [22].
  • The NRSE dsRNA can trigger gene expression of neuron-specific genes through interaction with NRSF/REST transcriptional machinery, resulting in the transition from neural stem cells with neuron-specific genes silenced by NRSF/REST into cells with neuronal identity that can express neuronal genes [23].
  • Phosphorylation of p53 is impaired in Zfp148(+/-) embryonic stem cells and in fetal germ cells from chimeric Zfp148(+/-) embryos [24].

Anatomical context of Stem Cells


Associations of Stem Cells with chemical compounds

  • To analyze the significance of this regulation during development, we have generated mice deficient in Csk, a kinase that phosphorylates this tyrosine, by gene targeting in embryonic stem cells [30].
  • Oct-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich sequence TTAAAATTCA, is present in P19 stem cells but disappears when the cells are induced to differentiate by retinoic acid (RA) [31].
  • Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression [32].
  • Prolonged exposure to lithium (three to 12 weeks) was associated with a dose-dependent progressive depletion of stem cells and their progeny [21].
  • 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination [33].

Gene context of Stem Cells

  • Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling [34].
  • Oct-3 has a conserved POU domain, but the remaining part is distinct from other POU domain-containing proteins such as Oct-1 and Oct-2. mRNA of 1.5 kb coding for Oct-3 is abundant in P19 stem cells but is dramatically repressed during RA-induced differentiation [31].
  • These findings reveal an unanticipated Shh-independent signaling pathway that controls progenitor cell identity and interneuron diversity in the ventral spinal cord [35].
  • These results provide new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal [36].
  • Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling [37].

Analytical, diagnostic and therapeutic context of Stem Cells


  1. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Kondo, M., Wagers, A.J., Manz, M.G., Prohaska, S.S., Scherer, D.C., Beilhack, G.F., Shizuru, J.A., Weissman, I.L. Annu. Rev. Immunol. (2003) [Pubmed]
  2. Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Stewart, C., Burke, B. Cell (1987) [Pubmed]
  3. An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells. La Thangue, N.B., Rigby, P.W. Cell (1987) [Pubmed]
  4. Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Le Mouellic, H., Lallemand, Y., Brûlet, P. Cell (1992) [Pubmed]
  5. Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia. Fialkow, P.J., Singer, J.W., Raskind, W.H., Adamson, J.W., Jacobson, R.J., Bernstein, I.D., Dow, L.W., Najfeld, V., Veith, R. N. Engl. J. Med. (1987) [Pubmed]
  6. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Ericson, J., Morton, S., Kawakami, A., Roelink, H., Jessell, T.M. Cell (1996) [Pubmed]
  7. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Wainwright, M.S., Martin, P.L., Morse, R.P., Lacaze, M., Provenzale, J.M., Coleman, R.E., Morgan, M.A., Hulette, C., Kurtzberg, J., Bushnell, C., Epstein, L., Lewis, D.V. Ann. Neurol. (2001) [Pubmed]
  8. Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. Haughey, N.J., Nath, A., Chan, S.L., Borchard, A.C., Rao, M.S., Mattson, M.P. J. Neurochem. (2002) [Pubmed]
  9. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. Laeng, P., Pitts, R.L., Lemire, A.L., Drabik, C.E., Weiner, A., Tang, H., Thyagarajan, R., Mallon, B.S., Altar, C.A. J. Neurochem. (2004) [Pubmed]
  10. Chemokine receptors, neural progenitor cells, and the AIDS dementia complex. Kao, A.W., Price, R.W. J. Infect. Dis. (2004) [Pubmed]
  11. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Loh, Y.H., Wu, Q., Chew, J.L., Vega, V.B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong, K.Y., Sung, K.W., Lee, C.W., Zhao, X.D., Chiu, K.P., Lipovich, L., Kuznetsov, V.A., Robson, P., Stanton, L.W., Wei, C.L., Ruan, Y., Lim, B., Ng, H.H. Nat. Genet. (2006) [Pubmed]
  12. Identification of intrinsic determinants of midbrain dopamine neurons. Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., Ericson, J. Cell (2006) [Pubmed]
  13. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Katayama, Y., Battista, M., Kao, W.M., Hidalgo, A., Peired, A.J., Thomas, S.A., Frenette, P.S. Cell (2006) [Pubmed]
  14. Pten, tumorigenesis, and stem cell self-renewal. Rossi, D.J., Weissman, I.L. Cell (2006) [Pubmed]
  15. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. Childs, R., Chernoff, A., Contentin, N., Bahceci, E., Schrump, D., Leitman, S., Read, E.J., Tisdale, J., Dunbar, C., Linehan, W.M., Young, N.S., Barrett, A.J. N. Engl. J. Med. (2000) [Pubmed]
  16. A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia. Castleberry, R.P., Emanuel, P.D., Zuckerman, K.S., Cohn, S., Strauss, L., Byrd, R.L., Homans, A., Chaffee, S., Nitschke, R., Gualtieri, R.J. N. Engl. J. Med. (1994) [Pubmed]
  17. Gene therapy of experimental brain tumors using neural progenitor cells. Benedetti, S., Pirola, B., Pollo, B., Magrassi, L., Bruzzone, M.G., Rigamonti, D., Galli, R., Selleri, S., Di Meco, F., De Fraja, C., Vescovi, A., Cattaneo, E., Finocchiaro, G. Nat. Med. (2000) [Pubmed]
  18. Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras. Hawley, R.G., Fong, A.Z., Ngan, B.Y., de Lanux, V.M., Clark, S.C., Hawley, T.S. J. Exp. Med. (1993) [Pubmed]
  19. Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity. Merchant, M.S., Woo, C.W., Mackall, C.L., Thiele, C.J. J. Natl. Cancer Inst. (2002) [Pubmed]
  20. PML is essential for multiple apoptotic pathways. Wang, Z.G., Ruggero, D., Ronchetti, S., Zhong, S., Gaboli, M., Rivi, R., Pandolfi, P.P. Nat. Genet. (1998) [Pubmed]
  21. The effect of lithium on murine hematopoiesis in a liquid culture system. Levitt, L.J., Quesenberry, P.J. N. Engl. J. Med. (1980) [Pubmed]
  22. Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene. Andrews, B.J., Herskowitz, I. Cell (1989) [Pubmed]
  23. A small modulatory dsRNA specifies the fate of adult neural stem cells. Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K., Gage, F.H. Cell (2004) [Pubmed]
  24. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Takeuchi, A., Mishina, Y., Miyaishi, O., Kojima, E., Hasegawa, T., Isobe, K. Nat. Genet. (2003) [Pubmed]
  25. Suppression of hematopoietic-progenitor-cell proliferation by ethanol and acetaldehyde. Meagher, R.C., Sieber, F., Spivak, J.L. N. Engl. J. Med. (1982) [Pubmed]
  26. Circulating erythroid progenitors in the anemia of prematurity. Shannon, K.M., Naylor, G.S., Torkildson, J.C., Clemons, G.K., Schaffner, V., Goldman, S.L., Lewis, K., Bryant, P., Phibbs, R. N. Engl. J. Med. (1987) [Pubmed]
  27. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Marine, J.C., Topham, D.J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., Ihle, J.N. Cell (1999) [Pubmed]
  28. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nichols, K.E., Crispino, J.D., Poncz, M., White, J.G., Orkin, S.H., Maris, J.M., Weiss, M.J. Nat. Genet. (2000) [Pubmed]
  29. Amyloid production in human myeloma stem-cell culture, with morphologic evidence of amyloid secretion by associated macrophages. Durie, B.G., Persky, B., Soehnlen, B.J., Grogan, T.M., Salmon, S.E. N. Engl. J. Med. (1982) [Pubmed]
  30. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Imamoto, A., Soriano, P. Cell (1993) [Pubmed]
  31. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Okamoto, K., Okazawa, H., Okuda, A., Sakai, M., Muramatsu, M., Hamada, H. Cell (1990) [Pubmed]
  32. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Jones, P.H., Watt, F.M. Cell (1993) [Pubmed]
  33. 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Konieczny, S.F., Emerson, C.P. Cell (1984) [Pubmed]
  34. Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Kielman, M.F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M.M., Roberts, S., Smits, R., Fodde, R. Nat. Genet. (2002) [Pubmed]
  35. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Pierani, A., Brenner-Morton, S., Chiang, C., Jessell, T.M. Cell (1999) [Pubmed]
  36. Core transcriptional regulatory circuitry in human embryonic stem cells. Boyer, L.A., Lee, T.I., Cole, M.F., Johnstone, S.E., Levine, S.S., Zucker, J.P., Guenther, M.G., Kumar, R.M., Murray, H.L., Jenner, R.G., Gifford, D.K., Melton, D.A., Jaenisch, R., Young, R.A. Cell (2005) [Pubmed]
  37. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V., Jessell, T.M., Briscoe, J. Cell (1997) [Pubmed]
  38. Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nakamura, T., Yao, R., Ogawa, T., Suzuki, T., Ito, C., Tsunekawa, N., Inoue, K., Ajima, R., Miyasaka, T., Yoshida, Y., Ogura, A., Toshimori, K., Noce, T., Yamamoto, T., Noda, T. Nat. Genet. (2004) [Pubmed]
  39. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Sicinski, P., Donaher, J.L., Parker, S.B., Li, T., Fazeli, A., Gardner, H., Haslam, S.Z., Bronson, R.T., Elledge, S.J., Weinberg, R.A. Cell (1995) [Pubmed]
  40. Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy. Withers-Ward, E.S., Amado, R.G., Koka, P.S., Jamieson, B.D., Kaplan, A.H., Chen, I.S., Zack, J.A. Nat. Med. (1997) [Pubmed]
  41. Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Bachar-Lustig, E., Rachamim, N., Li, H.W., Lan, F., Reisner, Y. Nat. Med. (1995) [Pubmed]
  42. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Willett, C.G., Boucher, Y., di Tomaso, E., Duda, D.G., Munn, L.L., Tong, R.T., Chung, D.C., Sahani, D.V., Kalva, S.P., Kozin, S.V., Mino, M., Cohen, K.S., Scadden, D.T., Hartford, A.C., Fischman, A.J., Clark, J.W., Ryan, D.P., Zhu, A.X., Blaszkowsky, L.S., Chen, H.X., Shellito, P.C., Lauwers, G.Y., Jain, R.K. Nat. Med. (2004) [Pubmed]
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