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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Axon contacts and acetylcholinesterase activity on chicken intrafusal muscle fiber types identified by their myosin heavy chain composition.

Muscle spindles of 8-week old chicken tibialis anterior muscles were examined to determine if specific intrafusal fiber types were also characterized by differences in motor innervation. Incubation with a monoclonal antibody against myosin heavy chains permitted the identification of strongly reactive, moderately reactive and unreactive intrafusal fibers. The innervation of each fiber type was evaluated in silver-impregnated sections, and in sections incubated with a monoclonal antibody against acetylcholinesterase. There was no acetylcholinesterase activity at the midequator of any fiber. At the juxtaequator and at the pole strongly reactive fibers typically exhibited fewer axon contacts and less acetylcholinesterase activity than unreactive and moderately reactive fibers. Differences were also recognized at neuromuscular junctions in the size and shape of acetylcholinesterase-positive sites. At the juxtaequator and at the pole strongly reactive fibers and moderately reactive fibers displayed significantly more small, dot-like acetylcholinesterase sites than unreactive fibers. On the contrary, the greatest number of larger, stout sites was found on unreactive fibers and the least number on strongly reactive fibers. Moderately reactive fibers took an intermediate position. The results indicate that myosin heavy chain-based chicken intrafusal fiber types are also set apart by differences in innervation.[1]


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