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Gene Review

ACHE  -  acetylcholinesterase

Gallus gallus

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Disease relevance of ACHE


Psychiatry related information on ACHE

  • 8. Moreover there is a possibility that it can be used as a therapeutic agent for the treatment of Alzheimer's disease, myasthenia gravia and glaucoma like some other inhibitors of AChE [6].

High impact information on ACHE


Chemical compound and disease context of ACHE


Biological context of ACHE


Anatomical context of ACHE

  • During further development, AChR was found to decrease markedly on the myotube surface, while acetylcholinesterase continued to increase [18].
  • By studying the synthesis transport and externalization of AChE we have defined the intracellular transport pathway and metabolic requirements for secretion in cultured muscle cells [7].
  • During differentiation of embryonic chick skeletal muscle in culture, elaboration of acetylcholine receptor (AChR) and acetylcholinesterase occurs shortly after myoblast fusion [18].
  • Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle [19].
  • This finding, together with the observation that basal lamina directs the formation of both AChR and AChE aggregates at regenerating neuromuscular junctions in vivo, leads us to hypothesize that a single component of the synaptic basal lamina causes the formation of both these synaptic specializations on regenerating myofibres [20].

Associations of ACHE with chemical compounds


Regulatory relationships of ACHE


Other interactions of ACHE


Analytical, diagnostic and therapeutic context of ACHE


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