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ACHE  -  acetylcholinesterase

Gallus gallus

 
 
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Disease relevance of ACHE

 

Psychiatry related information on ACHE

  • 8. Moreover there is a possibility that it can be used as a therapeutic agent for the treatment of Alzheimer's disease, myasthenia gravia and glaucoma like some other inhibitors of AChE [6].
 

High impact information on ACHE

 

Chemical compound and disease context of ACHE

 

Biological context of ACHE

 

Anatomical context of ACHE

  • During further development, AChR was found to decrease markedly on the myotube surface, while acetylcholinesterase continued to increase [18].
  • By studying the synthesis transport and externalization of AChE we have defined the intracellular transport pathway and metabolic requirements for secretion in cultured muscle cells [7].
  • During differentiation of embryonic chick skeletal muscle in culture, elaboration of acetylcholine receptor (AChR) and acetylcholinesterase occurs shortly after myoblast fusion [18].
  • Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle [19].
  • This finding, together with the observation that basal lamina directs the formation of both AChR and AChE aggregates at regenerating neuromuscular junctions in vivo, leads us to hypothesize that a single component of the synaptic basal lamina causes the formation of both these synaptic specializations on regenerating myofibres [20].
 

Associations of ACHE with chemical compounds

 

Regulatory relationships of ACHE

 

Other interactions of ACHE

 

Analytical, diagnostic and therapeutic context of ACHE

References

  1. Myogenic defect in acetylcholinesterase regulation in muscular dystrophy of the chicken. Linkhart, T.A., Yee, G.W., Wilson, B.W. Science (1975) [Pubmed]
  2. Molecular forms of acetylcholinesterase in chick muscle and ciliary ganglion: embryonic tissues and cultured cells. Kato, A.C., Vrachliotis, A., Fulpius, B., Dunant, Y. Dev. Biol. (1980) [Pubmed]
  3. Acetylcholinesterase in neural tube defects: a model using chick embryo amniotic fluid. Pilowsky, P.M., Hodgson, A.J., Chubb, I.W. Neuroscience (1982) [Pubmed]
  4. Plasma acetylcholinesterase in Duchenne muscular dystrophy. Sketelj, J., Sasel, B., Zupancic, N., Brzin, M. Exp. Neurol. (1983) [Pubmed]
  5. Exposure to diazinon alters in vitro retinogenesis: retinospheroid morphology, development of chicken retinal cell types, and gene expression. Paraoanu, L.E., Mocko, J.B., Becker-Roeck, M., Smidek-Huhn, J., Layer, P.G. Toxicol. Sci. (2006) [Pubmed]
  6. The inhibitory effect of tetramethylethylene diamine on water soluble and membrane bound acetylcholinesterase activity. al-Jafari, A.A. Int. J. Biochem. (1993) [Pubmed]
  7. Synthesis, transport and fate of acetylcholinesterase in cultured chick embryos muscle cells. Rotundo, R.L., Fambrough, D.M. Cell (1980) [Pubmed]
  8. Secretion of acetylcholinesterase: relation to acetylcholine receptor metabolism. Rotundo, R.L., Fambrough, D.M. Cell (1980) [Pubmed]
  9. Choline acetyltransferase, choline kinase, and acetylcholinesterase activities during the development of the chick ciliary ganglion. Burt, A.M., Narayanan, C.H. Exp. Neurol. (1976) [Pubmed]
  10. Developmental toxicity of desbromoleptophos in chicks: enzyme inhibition, malformations and functional deficits. Farage-Elawar, M., Duffy, J.S., Francis, B.M. Neurotoxicology and teratology. (1991) [Pubmed]
  11. Relative potencies of the four stereoisomers of isomalathion for inhibition of hen brain acetylcholinesterase and neurotoxic esterase in vitro. Jianmongkol, S., Berkman, C.E., Thompson, C.M., Richardson, R.J. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  12. Development and aging of cholinergic synapses. V. Changes in nicotinic cholinergic receptor binding in ciliary ganglia and irises of the chicken. Marchi, M., Yurkewicz, L., Giacobini, E., Fredrickson, T. Dev. Neurosci. (1981) [Pubmed]
  13. Effects of social stress on the toxicity of malathion in young chickens. Brown, C., Gross, W.B., Ehrich, M. Avian Dis. (1986) [Pubmed]
  14. Cloning and analysis of chicken acetylcholinesterase transcripts from muscle and brain. Randall, W.R., Rimer, M., Gough, N.R. Biochim. Biophys. Acta (1994) [Pubmed]
  15. Synaptic acetylcholinesterase of chicken muscle changes during development from a hybrid to a homogeneous enzyme. Tsim, K.W., Randall, W.R., Barnard, E.A. EMBO J. (1988) [Pubmed]
  16. Comparative localization of acetylcholinesterase and pseudocholinesterase during morphogenesis of the chicken brain. Layer, P.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  17. Spatiotemporal relationship of embryonic cholinesterases with cell proliferation in chicken brain and eye. Layer, P.G., Sporns, O. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  18. Appearance and disappearance of acetycholine receptor during differentiation of chick skeletal muscle in vitro. Prives, J., Silman, I., Amsterdam, A. Cell (1976) [Pubmed]
  19. Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle. Silman, I., di Giamberardino, L., Lyles, L., Couraud, J.Y., Barnard, E.A. Nature (1979) [Pubmed]
  20. Aggregates of acetylcholinesterase induced by acetylcholine receptor-aggregating factor. Wallace, B.G., Nitkin, R.M., Reist, N.E., Fallon, J.R., Moayeri, N.N., McMahan, U.J. Nature (1985) [Pubmed]
  21. Neurotrophic protein regulates muscle acetylcholinesterase in culture. Oh, T.H., Markelonis, G.J. Science (1978) [Pubmed]
  22. Avian muscular dystrophy: functional and biochemical improvement with diphenylhydantoin. Entrikin, R.K., Swanson, K.L., Weidoff, P.M., Patterson, G.T., Wilson, B.W. Science (1977) [Pubmed]
  23. Biochemical and cytochemical evidence indicates that coated vesicles in chick embryo myotubes contain newly synthesized acetylcholinesterase. Benson, R.J., Porter-Jordan, K., Buoniconti, P., Fine, R.E. J. Cell Biol. (1985) [Pubmed]
  24. Specific chemical and structural damage to proteins produced by synchrotron radiation. Weik, M., Ravelli, R.B., Kryger, G., McSweeney, S., Raves, M.L., Harel, M., Gros, P., Silman, I., Kroon, J., Sussman, J.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  25. Chicken retinospheroids as developmental and pharmacological in vitro models: acetylcholinesterase is regulated by its own and by butyrylcholinesterase activity. Layer, P.G., Weikert, T., Willbold, E. Cell Tissue Res. (1992) [Pubmed]
  26. Interaction of the four stereoisomers of soman (pinacolyl methylphosphonofluoridate) with acetylcholinesterase and neuropathy target esterase of hen brain. Johnson, M.K., Read, D.J., Benschop, H.P. Biochem. Pharmacol. (1985) [Pubmed]
  27. Innervation of arteriovenous anastomoses in the brood patch of the domestic fowl. Midtgård, U. Cell Tissue Res. (1988) [Pubmed]
  28. Developmental variations of tyrosine hydroxylase and acetylcholinesterase in embryonic and post-hatching chicken sympathetic ganglia. Fairman, K., Giacobini, E., Chiappinelli, V. Brain Res. (1976) [Pubmed]
  29. Axon contacts and acetylcholinesterase activity on chicken intrafusal muscle fiber types identified by their myosin heavy chain composition. Maier, A. Anat. Embryol. (1991) [Pubmed]
  30. Multiple effects of interferon on myogenesis in chicken myoblast cultures. Tomita, Y., Hasegawa, S. Biochim. Biophys. Acta (1984) [Pubmed]
  31. Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells. Tsim, K.W., Greenberg, I., Rimer, M., Randall, W.R., Salpeter, M.M. J. Cell Biol. (1992) [Pubmed]
  32. Regulation of acetylcholinesterase in avian heart. Studies on ontogeny and the influence of vagotomy. Jo, S.A., Higgins, D.M., Berman, H.A. Circ. Res. (1992) [Pubmed]
  33. An in vitro model of proliferation and differentiation of the chick retina: coaggregates of retinal and pigment epithelial cells. Vollmer, G., Layer, P.G. J. Neurosci. (1986) [Pubmed]
 
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