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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.

SAR around a known molecule with dual 5-HT(1D) antagonist and 5-HT(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT(1B), alpha(1), and D(2)).[1]

References

  1. Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors. Bueno, A.B., Gilmore, J., Boot, J., Broadmore, R., Cooper, J., Findlay, J., Hayhurst, L., Marcos, A., Montero, C., Mitchell, S., Timms, G., Tomlinson, R., Wallace, L., Walton, L. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
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