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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients.

In highly experienced HIV-1-infected patients, a ritonavir-boosted darunavir-containing regimen was associated with dramatic immunological and virological efficacy. Patients harbouring viruses with amprenavir-specific resistance profiles, such as I50V or V32I + I47V, failed on a darunavir/ritonavir-containing regimen. These key amprenavir mutations were also selected at the time of failure, suggesting their impact on darunavir efficacy.[1]

References

  1. Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients. Delaugerre, C., Mathez, D., Peytavin, G., Berthé, H., Long, K., Galperine, T., de Truchis, P. AIDS (2007) [Pubmed]
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